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abstract
Background: Surgery
followed by platinum-based chemotherapy is the standard of care for
MOGCTs, except for stage IA dysgerminoma and
stage IA grade 1 immature teratoma where
surveillance only is recommended. The role of adjuvant chemotherapy and
surgical
staging is debated.
Patients and Methods: Data from 144 patients with stage I MOGTs were collected among MITO centers (Multicenter Italian Trials in Ovarian Cancer)
and analysed.
Results: 55(38.2%)
patients were affected by dysgerminomas, 49(34%) by immature teratomas,
26(18.1%) by yolk sac tumors and 14(9.7%)
by mixed tumors. 73(50.7%) patients receive surgery
plus chemotherapy, while 71 (49.3%) patients underwent surgery alone.
The latter group included 32 dysgerminomas (14
IA-13 Ix, 3 IB, 2 IC), 34 immature teratomas (20 1A-13 IA grade 1, 6 Ix,
1
IB, 7 IC), 4 mixed tumors and 1 yolk sac tumor. 44
patients did not received chemotherapy, even if it would have been
indicated
by recommended approach. 94(65.3%) patients
received peritoneal surgical staging. 23(15.9%) developed a recurrence.
Incomplete
surgical staging was associated with recurrence
(p<0.05; OR 2.37) at Cox regression analysis. 7 patients died. 4
patients
were affected by yolk sac tumors, 2 by mixed tumors
and 1 by immature teratoma. 5 patients died for disease, 1 for acute
leukemia
and 1 for suicide. Prognostic parameters analyses
showed that yolk sac component is a predictor for survival (p<0.05) Five-years OS rates were 96.8% and 88.7% in surgically staged and incomplete staged group, while 93.8% and 94.1% in
standard treatment and in the surveillance group, respectively.
Conclusion: This study
shows that surveillance seems not to affect survival; chemotherapy
should be reserved for relapse resulting in
high cure rate. Incomplete peritoneal surgical
staging is associated with recurrence. Yolk sac histology worsens the
prognosis.
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