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Adhesiolysis is the term for the surgery that is performed to remove or divide adhesions so that normal anatomy and organ function can be restored and painful symptoms can be relieved. In some rare cases, adhesions form without visible or known tissue trauma.
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abstract
Twelve-year outcomes of laparoscopic adhesiolysis in patients with chronic abdominal pain: A randomized clinical trial
Background
Laparoscopic
adhesiolysis as a therapy for chronic pain is still controversial, and
long-term effects are not known; therefore, our aim was to evaluate
long-term effects of laparoscopic adhesiolysis for the treatment of
chronic abdominal pain believed to be related to intraperitoneal
adhesions.
Methods
A total
of 100 patients with abdominal pain attributed to adhesions were
randomized to laparoscopic adhesiolysis or a placebo group with
laparoscopy alone. Pain relief was assessed after 12-year follow-up.
Results
A total of 73% of patients fulfilled the long-term follow-up. Compared to the placebo group (n = 31), patients in the adhesiolysis group (n = 42) were significantly less often pain-free (8 vs 13, P = .033, relative risk [RR] = 1.3) and to have a greater intake of analgesics (26 vs 16, P = .379,
RR = 1.2, 95% confidence interval 0.8–1.8). Moreover, the adhesiolysis
group sought medical consultations more frequently (14 vs 6, P = .186, RR = 1.33, 95% confidence interval 0.9–1.9), and had an increased rate of additional operation (8 vs 1, P = .042, RR = 1.67, 95% confidence interval 1.208–2.318). Both groups had improved pain and quality-of-life scores.
Conclusion
This
is the first, long-term, placebo-controlled trial regarding the use of
laparoscopic adhesiolysis for treating chronic abdominal pain.
Laparoscopic adhesiolysis was less beneficial than laparoscopy alone in
the long term. Secondly, there appeared to be a powerful, long-lasting
placebo effect of laparoscopy. Because adhesiolysis is associated with
an increased risk of operative complications, avoiding this treatment
may result in less morbidity and health care costs.
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