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abstract
Unclassifiable Malignant Extraovarian Sex Cord-Stromal Tumors: Report of 3 Cases and Review of Extraovarian Sex Cord-Stromal Tumors.
We report 3 cases of primary extraovarian unclassifiable
malignant sex cord-stromal tumors. In all cases, the tumors involved the
pelvis, peritoneum, and/or omentum and the morphologic features were
essentially those of a poorly differentiated malignant neoplasm. A
diagnosis of sex cord-stromal tumor was made on the basis of expression
of several markers of ovarian sex cord-stromal tumors and exclusion of
other neoplasms. In 1 case, an elevated serum testosterone was present
at tumor progression. In reporting these cases, we draw attention to the
problems in establishing a diagnosis that can be attributed to the
extreme rarity of sex cord-stromal tumors in an extraovarian location
and the rarity of unclassifiable malignant sex cord-stromal tumors in
general, resulting in pathologists not considering this diagnosis. We
review sex cord-stromal tumors occurring in an extraovarian location.
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