|
|
|
|
|
|
|
|
Diagnostic accuracy of Cancer Antigen 125 (CA125) for endometriosis in symptomatic women: A multi-center study
Abstract
Study Objective
To
assess the diagnostic accuracy of serum Cancer Antigen 125 (CA 125) ≥30
units/milliliter (u/ml) for diagnosing endometriosis in symptomatic
women.
Study Design
Prospective
observational cohort study including patients with symptoms of pelvic
pain or subfertility undergoing elective diagnostic laparoscopy at two
tertiary referral hospitals. We excluded patients suspected to have
other gynecological pathology. We evaluated the accuracy of serum CA 125
(index test) with histologically confirmed endometriosis (reference
standard).
Main Results
Fifty-eight
consecutive women recruited between October 2013 to March 2015. Women
with endometriosis had a higher CA 125 level than those without
endometriosis (mean 54.7 +/−71.6 vs 16.2 +/− 8.0). The specificity of CA
125 ≥30 u/ml was 96% and sensitivity was 57%. The positive likelihood ratio for the histological
presence of endometriosis with a CA 125 ≥ 30 u/ml was 15.8 providing a post-test probability of 94% in
women with pelvic pain or subfertility. The area under the curve, 0.85 indicates high test accuracy.
Conclusions
CA
125 ≥30 u/ml is highly predictive of endometriosis in women with
symptoms of pain and/or subfertility. CA 125 should be considered as a
rule-in test for expediting the diagnosis and management of
endometriosis, CA 125 <30 u/ml is, however, unable to rule out
endometriosis.
0 comments :
Post a Comment
Your comments?
Note: Only a member of this blog may post a comment.