OA: High-grade serous ovarian cancer 3 years after bilateral salpingectomy (stage 1V) Ovarian Cancer and Us OVARIAN CANCER and US Ovarian Cancer and Us

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Saturday, December 17, 2016

OA: High-grade serous ovarian cancer 3 years after bilateral salpingectomy (stage 1V)

 High-grade serous ovarian cancer 3 years after bilateral salpingectomy: A case report
 View Abstract      (open access) Download PDF 
Although epithelial ovarian cancer commonly originates from the ovarian surface epithelium and/or ovarian inclusion cysts, it was recently proposed that high‑grade serous ovarian cancer (HGSC) develops from the fallopian tubes. In our department, we encountered a case of HGSC that contradicts the hypothesis of a tubal origin for HGSC. A 51-year-old postmenopausal woman had undergone hysterectomy, left oophorectomy and bilateral salpingectomy for uterine myoma. Three years later, the patient was diagnosed with stage IV ovarian cancer and underwent primary debulking surgery. The pathological examination revealed HGSC, although there was no evidence of serous tubal intraepithelial carcinoma or any other type of cancer in the previously resected left ovary and bilateral fallopian tubes. Moreover, p53 overexpression was not detected in the right ovarian cancer specimen, while paired box gene 8, a marker of fallopian tube epithelium, was highly expressed. Therefore, HGSC may develop from an inclusion cyst with metaplasia of from the ovarian surface epithelium.

 In conclusion, we herein report a case of HGSC that
developed 3 years after BS, contradicting the hypothesis of a
tubal origin. There was also no region of STIC or p53 expression
detected in the present case. Based on these findings, we
consider that other mechanisms must be responsible for carcinogenesis
in HGSC in patients without p53 mutations.


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