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Polycystic ovary syndrome and risk of endometrial, ovarian, and breast cancer: a systematic review | Fertility Research and Practice | Full Text
Results
We identified 11 individual
studies and 3 meta-analyses on the associations between PCOS and
endometrial cancer, 8 studies and 1 meta-analysis for ovarian cancer,
and 10 studies and 1 meta-analysis for breast cancer. Multiple studies
reported that women with PCOS were at a higher risk for endometrial
cancer; however, many did not take into account body mass index (BMI), a
strong and well-established risk factor for endometrial cancer. The
association with ovarian cancer was less clear, but a potentially
increased risk of the borderline serous subtype was reported by two
studies. No consistent association between PCOS risk and breast cancer
was observed.
Background
Polycystic
ovary syndrome (PCOS) is a complex endocrine disorder characterized by
oligomenorrhea, hyperandrogenism, and polycystic ovaries. It has an
estimated prevalence of 4–21% in reproductive aged women depending on
the diagnostic criteria and population examined [1, 2, 3, 4, 5, 6, 7]. In the U.S. it has been estimated that 5 million women may have PCOS [8].
PCOS is associated with metabolic abnormalities including dyslipidemia,
insulin resistance, and type II diabetes and is also one of the most
common causes of reduced fertility [9, 10]. The altered metabolic and hormonal environment among women with PCOS may increase their risk of some types of cancer.....
Oligomenorrhea is a condition in which you have infrequent menstrual periods.
Hyperandrogenism, also known as androgen excess, is a medical condition characterized by excessive levels of androgens (male sex hormones such as testosterone) in the female body and the associated effects of the elevated androgen levels.
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