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medscape
Abstract
Background Main Text Conclusions
References
Conclusions
Although it is important to understand the
strengths and limitations of both RCTs (efficacy studies) and
observational studies (effectiveness studies), none of the study designs
should be considered in isolation since all types of evidence rely
primarily on the rigour with which individual studies were conducted
(regardless of the methodological approach) and the care with which they
are interpreted.[19] Interpretation of the results obtained
from both RCTs and observational studies can help understand the
efficacy/effectiveness and safety of a therapeutic option. Meta-analyses
using both RCT and observational studies should be used to highlight
some questions that neither a RCT, nor an observational study would have
the ability to solve by themselves.....
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