(BRCA2) Prostate cancer team cracks genetic code to show why inherited disease can turn lethal Ovarian Cancer and Us OVARIAN CANCER and US Ovarian Cancer and Us

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Wednesday, January 11, 2017

(BRCA2) Prostate cancer team cracks genetic code to show why inherited disease can turn lethal



CNW Group
(press release)

TORONTO, Jan. 9, 2017 /CNW/ - Canadian and Australian prostate cancer researchers have discovered a key piece in the genetic puzzle of why men born with a BRCA2 mutation may develop aggressive localized cancers that resist treatment and become lethal for up to 50% of patients within five years.
The findings, published online today in Nature Communications, show that BRCA2-associated tumours are already pre-set to be aggressive, even before treatment. This is because the genes normally involved in regulating cell growth and division are abnormal in the BRCA2-associated cancers right from the get-go and therefore are resistant to therapy right up front, says co-principal investigator Dr. Robert Bristow, clinician-scientist at Princess Margaret Cancer Centre, University Health Network. He talks about the research at https://youtu.be/dXlntpaWtaI....

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