abstract:
Multidisciplinary approach in the management of advanced ovarian cancer patients: A personalized approach. Results from a specialized ovarian cancer unit
Published online: January 20, 2017
Highlights
- •Multidisciplinary approach allows patients selection for different strategies in advanced ovarian cancer patients.
- •Patients' and tumor's related criteria are important in defining the treatment strategy in advanced ovarian cancer patients.
- •A structured decisional algorithm, including different medical specialties allows optimization of care.
Objective
The
aim of the present study was to evaluate the impact of a
multidisciplinary approach in patients' selection with advanced ovarian
cancer (AOC) for different therapeutic strategies.
Methods
Patients
referred at our institution between 2009 and 2012 for AOC were
included. Primary multidisciplinary evaluation was performed in all
patients. Different strategies included: 1. patients referred to primary
neoadjuvant chemotherapy (NACT) and interval surgery (IDS) (group A);
2. patients considered for surgical exploration. After surgical
exploration, patients were either considered for primary debulking (PDS;
group B), or NACT (group C).
Results
A
total of 363 patients were included. Of 38 patients (10.5%) in group A,
24 (63%) had sovradiaphragmatic/multiple liver metastases; 14 (37%)
were excluded for PDS for anestehesiologic/medical reasons. Of 325
(89.5%) considered for surgical exploration, 295 (91%; group B) had
primary surgery with debulking intent (N: 277) and were cytoreduced to
no macroscopic disease (R0: N:200; 68%) o minimal RD < 5 mm (R1:
N:77; 26%) or palliative intent (N:18; 6%); 30 (9%; group C) were
referred for NACT. Of those, 27 (90%) underwent IDS, 3 had progressive
disease. Overall survival (OS) and progression free survival (PFS) was
different between the groups: OS: Group A: 34 months; Group B:
59 months; Group C: 29 months; p < 0.001. PFS: Group A: 10 months; Group B; 21 months; Group C: 12 months; p < 0.001.
Conclusions
A
multidisciplinary approach to patients referred to a tertiary center
with AOC allows optimization of the treatment strategy, based on
patients' characteristics (age, performance/nutritional status,
comorbidities, functional status) and tumor diffusion (evaluated pre-
and intraoperatively).
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