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Showing posts with label MSI. Show all posts
Showing posts with label MSI. Show all posts
Saturday, May 26, 2012

[Biomarker for colorectal cancer] - Lynch Syndrome/MSI/KRAS/BRAF

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[Biomarker for colorectal cancer] Abstract Discovery of usable molecular biomarkers is the step closer to a realization of personalize...
Sunday, April 22, 2012

abstract: Postmenopausal hormone therapy is associated with a reduced risk of colorectal cancer lacking CDKN1A expression

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  http://cancerres.aacrjournals.org/content/early/2012/04/17/0008-5472.CAN-11-2619.abstract     Abstract Experimental studies have show...
Saturday, April 21, 2012

abstract: Unusual DNA mismatch repair-deficient tumors in Lynch syndrome: a report of new cases and review of the literature.

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Unusual DNA mismatch repair-deficient tumors in Lynch syndrome: a report of new cases and review of the literature. Hum Pathol. 2012 Apr 1...
Thursday, April 05, 2012

abstract: Microsatellite Instability in Saliva from Patients with Hereditary Non-polyposis Colon Cancer (HNPCC/Lynch Syndrome) and Siblings Carrying Germline Mismatch Repair Gene Mutations

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Microsatellite Instability in Saliva from Patients with Hereditary Non-polyposis Colon Cancer and Siblings Carrying Germline Mismatch Repair...
Wednesday, February 01, 2012

abstract: Clinical Effects of Adjuvant Active Specific Immunotherapy Differ between Patients with Microsatellite-Stable and Microsatellite-Instable Colon Cancer

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Blogger's Note:  the abstract does not detail MSI-L/MSI-H (colon cancer in Lynch Syndrome) Experimental Design: Microsatellite statu...
Tuesday, January 18, 2011

full free access: Absence of microsatellite instability in mucinous carcinomas of the breast (Lynch Syndrome)

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Note : some key excerpt; see also Supplemental Tables 1-4 "Microsatellite instability ( MSI ) is a form of genetic instability that ...
Monday, September 27, 2010

Prognostic value of microsatellite instability (MSI) and PTEN expression in women with endometrial cancer: results from studies of the NCIC Clinical Trials Group (NCIC CTG)

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Abstract AIM: The impact of PTEN status and microsatellite instability (MSI) on the prognosis of women with endometrial cancer is c...
Thursday, September 16, 2010

Genetic Instability Influences Drug Response in Cancer Cells (abstract)

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Abstract One of the main reasons why most patients with advanced cancer are not curable with the therapies available is the broad heteroge...
Wednesday, August 04, 2010

Low Frequency of Lynch Sydrome among Young Patients with Non-Familial Colorectal Cancer

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Note : "young" referred to as those less than 50 yrs age
Friday, July 09, 2010

abstract: The Clinical Molecular Diagnostics Laboratory and Microsatellite Instability Testing of Colorectal Cancer

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Note: this abstract gives an overview of Lynch Syndrome testing eg. immunohistochemistry (testing of tumour); Microsatellite (MSI); improve...

full free access: Genomic aberrations in borderline ovarian tumors

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Note : this paper is long and technical but of importance given, in part, the connection to Lynch Syndrome (MSI testing, microsatellite). Mi...
Saturday, May 15, 2010

Expert Reviews full access: On the advent of MSI testing of all colorectal cancers and a substantial part of other Lynch syndrome-related neoplasms

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Worldwide, more than 1 million people present with colorectal cancer (CRC) annually. Of these, 2–5% occur in the context of Lynch syndrome ...
Friday, May 07, 2010

Clinical Significance of Microsatellite Instability in Sporadic Epithelial Ovarian Tumors

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Abstract: CONCLUSION: MSI was infrequent in ovarian tumors, including both borderline and malignant tumors. MSI was found to be uncommon ...

Microsatellite instability in colorectal cancer. abstract

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Thursday, May 06, 2010

Atypical identification of Lynch syndrome by immunohistochemistry and microsatellite instability analysis on jejunal adenocarcinoma

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Note: abstract/free full text (pdf) *this case describes a patient with many different cancers in the family including breast cancer, MSH6...
Friday, April 23, 2010

Colon Cancer: Microsatellite instability stymies doctors - Cancer Network

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Note: MSI has been/is being studied also in ovarian cancer (w/without Lynch Syndrome genes)
Tuesday, April 20, 2010

Table 1 : Mismatch repair deficient colorectal cancer in the era of personalized treatment : Nature Reviews Clinical Oncology

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Thursday, January 07, 2010

full free access-focus on Lynch Syndrome Ultradeep Sequencing of a Human Ultraconserved Region Reveals Somatic and Constitutional Genomic Instability

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" Genomic instability is a common trait of cancer cells and plays a pivotal role in promoting carcinogenesis in several hereditary tum...