Saturday, January 09, 2010
Optimal management of recurrent ovarian cancer. [Int J Gynecol Cancer. 2009] - PubMed result
Note: several years ago Cary Vera Garcia (deceased) published an article about ovarian cancer as a chronic disease. It was an excellent article and she felt using the term chronic as it may apply to ovarian cancer 'Devalued a Survivor's Challenge'. Dr Markman wrote a response concerning the clinical use of the word 'chronic' as it may apply to ovarian cancer. So, 'very serious chronic' is a new term which is interesting.
Sandi
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Int J Gynecol Cancer. 2009 Dec;19 Suppl 2:S40-3.
Optimal management of recurrent ovarian cancer.
Markman M.
Department of Gynecologic Medical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX 77030, USA. mmarkman@mdanderson.org
The development of an optimal management approach in recurrent ovarian cancer requires careful consideration of a number of important factors including (a) response to and severity/persistence of toxicity associated with prior therapy, (b) existence of relevant trial data (particularly phase 3 studies), (c) patient interest in participating in clinical trials, (d) cost of (and ability to pay for) particular anti-neoplastic drug regimens, and (e) patient choice. It is likely that the increasing availability of biologically active novel agents (and combination programs) in this clinical setting will add to the difficulty of defining optimal therapy in recurrent/resistant ovarian cancer, which, in many individuals, can be reasonably considered a very serious chronic disease process.
abstract: Symptom control pts with recurrent OC: measuring the benefit of palliative chemotherapy in women with platinum refractory/resistan
Symptom control in patients with recurrent ovarian cancer: measuring the benefit of palliative chemotherapy in women with platinum refractory/resistant ovarian cancer.
Changing the paradigm in the treatment of platinum-sensitive recurrent ovarian cancer: from platinum doublets to nonplatinum doublets and adding antia
Changing the paradigm in the treatment of platinum-sensitive recurrent ovarian cancer: from platinum doublets to nonplatinum doublets and adding antiangiogenesis compounds.
Friday, January 08, 2010
Biological Mechanisms Linking Obesity and Cancer Risk: New Perspectives - Annual Review of Medicine, 61(1):301 - Abstract
"While public health policies aimed at curbing the underlying causes of the obesity epidemic are being implemented, there is a parallel need to better understand the biological processes linking obesity and cancer as a prerequisite to the development of new approaches to prevention and treatment."
Progressive Multifocal Leukoencephalopathy in Patients on Immunomodulatory Therapies* - Annual Review of Medicine, 61(1):35 - Abstract
Laboratory of Molecular Medicine and Neuroscience, Division of Intramural Research, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892; email: majorg@ninds.nih.gov
"Progressive multifocal leukoencephalopathy (PML) is a demyelinating disease of the white matter of the human brain caused by lytic infection of oligodendrocytes with the human polyomavirus JCV. Although the majority of PML cases occur in severely immune-suppressed individuals, with HIV-1 infection as the predominant factor, PML has been increasingly diagnosed in patients treated with biological therapies such as monoclonal antibodies that modulate immune system functions...."
Patient-Centered Medical Homes in Ontario | Health Care Reform
Some interesting observations in this article including:
"Per capita, Canada has one third fewer active physicians than the United States, 15% more primary care physicians, and half as many specialists. Consequently, the heavy responsibilities of Canadian specialists promote shared care with family physicians, and specialists rarely see patients without referral. In the United States, only 30% of visits to specialists occur through referrals,5 and patients are likely to see multiple specialists."
April 17-21, 2010 in Washington, DC. - AACR 101st Annual Meeting 2010
New Concepts in Organ Site Research:
Recent Advances in Ovarian Cancer Research
Co-Chairpersons: Christopher P. Crum, Brigham and Women's Hospital, Boston, MA, and Shelley S. Tworoger, Brigham and Women's Hospital, Boston, MA
* David D. Bowtell, Peter MacCallum Cancer Center, Melbourne, Australia
* Elise C. Kohn, National Cancer Institute, Bethesda, MD
* Martin Widschwendter, Institute for Women's Health, University College London, London, United Kingdom
* Alicja Wolk, National Institute of Environmental Medicine, Stockholm, Sweden
Dear Advocates: (sponsorship) 2010 ACMG Annual Clinical Genetics Meeting
January 8th, 2009:
Dear advocates,
We are now accepting applications for the Advocates Partnership Program at the American College of Medical Genetics (ACMG) Annual Clinical Genetics Meeting, March 24-28 in Albuquerque, New Mexico.
The Advocates Partnership Program aims to foster new connections among members of the genetics community. Highlights for participants include engaging in thought-provoking discussions about clinical genetics and informatics, and attending exclusive daily briefings with ACMG staff and professionals working in your area of interest. The ACMG preliminary meeting schedule is available at http://www.acmgmeeting.net/schedule.php
Acceptance into the Advocates Partnership Program includes waived full registration to the ACMG Annual Clinical Genetics Meeting. Furthermore, participants will be reimbursed for up to $250 for transportation, hotel accommodations, or airfare.
We welcome applications from individuals interested in the field of clinical genetics. Individuals who hold ACMG membership or those who could be a potential candidate for membership are not eligible to apply for the Advocates Partnership Program.
To apply, please download the application form from http://www.geneticalliance.org/advocates.opportunities.
Please return it to tmurza@geneticalliance.org no later than Friday, February 5, 2010.
Priority will be given to individuals who previously have not participated in the Advocates Partnership Program.
Please forward this message to your friends and colleagues.
If you have any questions, please contact Tetyana Murza at tmurza@geneticalliance.org or (202) 966-5557 ext. 205. We look forward to hearing from you.
Best,
Genetic Alliance
Thursday, January 07, 2010
press release: Theralase Technologies Research Successfully Destroys Breast Cancer cells
preclinical studies to come in 2010
full free access-focus on Lynch Syndrome Ultradeep Sequencing of a Human Ultraconserved Region Reveals Somatic and Constitutional Genomic Instability
"Genomic instability is a common trait of cancer cells and plays a pivotal role in promoting carcinogenesis in several hereditary tumours. One of the best-known examples is the Lynch syndrome, an autosomal dominant condition associated with heterozygous mutations in mismatch repair (MMR) genes. During their lifespan, individuals affected by the Lynch syndrome...... The tumourigenic process starts when mutations hit oncogenes and/or tumour suppressors, often in actively renovating tissues such as endometrium, ovary, and colon. In the latter case, the genetic condition is known as hereditary non-polyposis colorectal cancer (HNPCC), which represents the most common form of inherited colorectal cancer.... Since more than 90% of HNPCC show MSI this has become a common diagnostic marker..."
Subscribe to:
Posts
(
Atom
)
