abstract: An effect from anticipation also in hereditary nonpolyposis colorectal cancer families without identified mutations.(Lynch Syndrome)

Note: this would apply to the many with no known mutations in the many genetic syndromes (eg. BRCA, Peutz-Jeghers Syndrome...)

"This observation suggests that anticipation may apply also to families without identified mutations and serves as a reminder to initiate surveillance programmes at young age also in HNPCC families with undefined genetic causes."

Editorial: Targeted Chemotherapy? Platinum in BRCA1-Dysfunctional Breast Cancer

A Link between mir-100 and FRAP1/mTOR in Clear Cell Ovarian Cancer --joint study Japan/U.S.

Note: This abstract is highly technical, but the significance is that there is a focus on clear cell ovarian cancer.

"...Our experiments have revealed strong candidate miRNAs and their target genes that may contribute to the pathogenesis of clear cell ovarian cancer..."

Hereditary breast and ovarian cancer: Referral source for genetic assessment and communication regarding assessment with nongenetic clinicians in the

Hereditary breast and ovarian cancer: Referral source for genetic assessment and communication regarding assessment with nongenetic clinicians in the community setting:

2009 Yi and St Louis Ovarian Cancer at OneTrueMedia.com

see the Montage from last year's (2009) ovarian cancer ACOR & friends August weekend

Make photo slide shows at www.OneTrueMedia.com

Ovarian stimulation and emergency in vitro fertilization for fertility preservation in cancer patients.

WWOX tumour suppressor gene polymorphisms and ovarian cancer pathology and prognosis.

"One-third of ovarian tumours show loss of WWOX expression, and this loss significantly associates with clear cell and mucinous histology, advanced stage, low progesterone receptor expression and poor survival, suggesting that WWOX status affects ovarian cancer progression and prognosis."

e-blogger Dave: The Invisible Stakeholder - Patient is not a third-person word.

Doctors’ Blind Spot? The Patient | Conversations...

FDA (U.S.)Basics - new website

The tool answers questions such as (and more):

How and where do I find out if a drug is approved for use?
Why are there still food recalls?
How do I report a pet food compliant?
You can also submit your own questions, provide feedback, and view interviews with FDA staff.

Bazedoxifene, a selective estrogen receptor modulator: effects on the endometrium, ovaries, and breast from a randomized controlled trial in osteoporo

Bazedoxifene, a selective estrogen receptor modulator: effects on the endometrium, ovaries, and breast from a randomized controlled trial in osteoporotic postmenopausal women

Ovarian status in healthy postmenopausal women: follow-up 12 months after transvaginal ultrasound.

Depression, anxiety and body image after treatment for invasive stage one epithelial ovarian cancer.

Urinary angiostatin levels are elevated in patients with epithelial ovarian cancer.

Note: further research required

Immunohistochemical analysis of hMLH1 and hMSH2 proteins in serous ovarian tumours.

Note: Immunohistochemical = tumour sample; hMLH1 and hMSH2 (2 of) Lynch Syndrome genes

 "Our results suggest that hMLH1 and hMSH2 proteins may be involved in ovarian carcinogenesis."

AACR upcoming conference: Cancer Epigenetics

"The study of epigenetic mechanisms in cancer, such as DNA methylation, histone modifications, nucleosome positioning and non-coding RNA expression, has revealed a plethora of events that contribute to the neoplastic phenotype through stable changes in the expression of genes critical to transformation pathways...Therefore, improved understanding of normal epigenetic programs is necessary to better understand malignancy-specific epigenetic alterations.....numerous other clinical applications of the field being explored in areas such as cancer screening and early detection, prevention, classification for epidemiology and prognostic purposes, and predicting outcomes after standard therapy."

media report: monoacylglycerol lipase (or MAGL for short) Cancer cells co-opt fat metabolism pathway to become more malignant

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Exons: Researchers Sequence 'Exomes' Of New Strategy For Finding Disease Genes

"....demonstrated the feasibility and value of a new strategy for identifying relatively rare genetic variants that may cause or contribute to disease....The new strategy involves isolating and sequencing all exons which are the parts of the human genome that contain the information needed to produce proteins, the building blocks of the body. The complete set of exons – referred to as the "exome" – makes up only one percent of the human genome. By selecting only the exome to sequence, the important information about an individual can be obtained at a much lower cost than sequencing a person's entire genome."

Medical News: FDA (U.S.) Pleads for More Research on Anemia Drugs

2010 Who Is Responsible? The Role of Family Physicians in the Provision of Supportive Cancer Care

Note: the issues from the family physicians' perspective

Editorial: Who Should Follow Our (Cancer) Patients?

Note: Good plain english article generalizing the issues - $$/capacity/knowledge