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Wednesday, August 22, 2012

Head of Education and Supportive Services with Target Ovarian Cancer | 348339 (job posting UK)



  • Location: Islington, London
  • Contract type: Permanent
  • Salary: £30,400 for 30 hours per week (£38,000 pro rata)
  • Date posted: 22 August 2012
  • Recruiter: Target Ovarian Cancer



Sent from my iPhone

Systematic lymphadenectomy in ovarian cancer at second-look surgery: a randomised clinical trial



http://www.nature.com/bjc/journal/v107/n5/full/bjc2012336a.html


Sent from my iPhone

Ann_Oncology - The impact of second to sixth line therapy on survival of relapsed ovarian cancer after primary taxane/platinum-based therapy



http://m.annonc.oxfordjournals.org/content/early/2012/08/21/annonc.mds203.short?rss=1?rss=1?rss=1


Sent from my iPhone

The advantage of letrozole over tamoxifen in the BIG 1-98 trial is consistent in younger postmenopausal women and in those with chemotherapy-induced menopause.



http://www.ncbi.nlm.nih.gov/m/pubmed/21892704/


Sent from my iPhone

New medical technology improves image quality and reduces radiation PET/MRI



http://www.news-medical.net/post.aspx?id=5efbfab4-a612-47ad-8af0-75c7e4b6fc3c


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Taxanes for Ovarian Cancer during Pregn - PubMed Mobile



Taxanes for Ovarian Cancer during Pregnancy: A Systematic Review.




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Adnexal masses suspected to be benign treated with laparoscopy



Adnexal masses suspected to be benign treated with laparoscopy.




Tuesday, August 21, 2012

Many Americans see specialists for primary care: study



Many Americans see specialists for primary care: study
http://www.reuters.com/article/idUSBRE87K13W20120821

A Patient “Disrespected” - Cancer Network



A qualitative study on the term CAM: is there a need to reinvent the wheel?



Conclusions: CAM and other related terms could be used more effectively, provided they are used in the proper context. It appears difficult for the time being to reach a consensus on the definition of the term CAM due to the uncertainty of the positioning of CAM in the contemporary healthcare systems. While umbrella terms such as CAM and IHC are useful in the context of research, policy making and education, relevant stakeholders should limit the use of those 

A qualitative study on the term CAM: is there a need to reinvent the wheel?

Background:
As complementary and alternative medicine (CAM) has developed extensively, uncertainty about the appropriateness of the terms CAM and other CAM-related terms has grown both in the research and practice communities. Various terms and definitions have been proposed over the last three decades, highlighting how little agreement exits in the field. Contextual use of current terms and their respective definitions needs to be discussed and addressed.
Methods:
Relying upon the results of a large international Delphi survey on the adequacy of the term CAM, a focus group of 13 international experts in the field of CAM was held. A forum was also set up for 28 international experts to discuss and refine proposed definitions of both CAM and integrative healthcare (IHC) terms. Audio recordings of the meeting and forum discussion threads were analyzed using interpretive description.
Results:
Multiple terms to describe the therapies, products, and disciplines often referred to as CAM, were considered. Even though participants generally agreed there is a lack of optimal definitions for popular CAM-related umbrella terms and that all terms that have so far been introduced are to some extent problematic, CAM and IHC remained the most popular and accepted terms by far. The names of the specific disciplines were also deemed adequate in certain contexts. Focus group participants clarified the context in which those three terms are appropriate. Existing and emergent definitions of both CAM and integrative healthcare terms were discussed.

Conclusions:
CAM and other related terms could be used more effectively, provided they are used in the proper context. It appears difficult for the time being to reach a consensus on the definition of the term CAM due to the uncertainty of the positioning of CAM in the contemporary healthcare systems. While umbrella terms such as CAM and IHC are useful in the context of research, policy making and education, relevant stakeholders should limit the use of those terms.

ScienceDirect.com - European Journal of Cancer - Support of the ‘fallopian tube hypothesis’ in a prospective series of risk-reducing salpingo-oophorectomy specimens



http://www.sciencedirect.com/science/article/pii/S0959804912006041


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Lynch syndrome - review of patient testing



Discussion
Family history of colon cancer is documented for the majority of individuals although this varies by site. Very few individuals are tested for LS at any site, representing a potential under diagnosis of this hereditary condition in patients and their families. When testing is performed, there does not seem to be a preference for immunohistochemistry or microsatellite instability testing for any site.

http://www.google.ca/reader/i/?source=mog&hl=en&gl=ca#stream/user%2F16646332178603240200%2Fstate%2Fcom.google%2Freading-list


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Journal of Ovarian Research | Abstract | High preoperative blood levels of HE4 predicts poor prognosis in patients with ovarian cancer-open access



http://www.ovarianresearch.com/content/5/1/20/abstract

CMA touts one-on-one doctor-patient interaction over ‘gizmos’ - The Globe and Mail



JCO: Prevention of Delayed Nausea: A University of Rochester Cancer Center Community Clinical Oncology Program Study of Patients Receiving Chemotherapy



http://m.jco.ascopubs.org/content/early/2012/08/20/JCO.2011.39.8123.short?rss=1

Monday, August 20, 2012

Nearly half of U.S. doctors struggle with burnout: study



Nearly half of U.S. doctors struggle with burnout: study
http://www.reuters.com/article/idUSBRE87J0RJ20120821

Body composition changes in females treated for breast cancer: a review of the evidence




Body composition changes in females treated for breast cancer: a review of the evidence

Abstract  
Body composition changes cannot be precisely captured using body weight or body mass index measures. Therefore, the primary
purpose of this review was to characterize the patterns of body composition change in females treated for breast cancer including
only studies that utilize imaging technologies to quantify adipose tissue and lean body mass (LBM). We reviewed PubMed for
studies published between 1971 and 2012 involving females diagnosed with breast cancer where computed axial tomography , dual-energy
X-ray absorptiometry, or magnetic resonance imaging were employed for body composition assessment. Of the initial 440 studies,
106 papers were evaluated and 36 papers met all eligibility criteria (15 observational and 21 intervention trials). Results
of these studies revealed that body weight did not consistently increase. Importantly, studies also showed that body weight
did not accurately depict changes in lean or adipose tissues. Further findings included that sarcopenic obesity as a consequence
of breast cancer treatment was not definitive, as menopausal status may be a substantial moderator of body composition. Overall,
the behavioral interventions did not exhibit consistent or profound effects on body composition outcomes; approximately half
showed favorable influence on adiposity while the effects on LBM were not apparent. The use of tamoxifen had a clear negative
impact on body composition. The majority of studies were conducted in predominantly white survivors, highlighting the need
for trials in minority populations. Collectively, these studies were limited by age, race, and/or menopause status matched
control groups, overall size, and statistical power. Very few studies simultaneously collected diet and exercise data—two
potential factors that impact body composition. Future breast cancer trials should prioritize precise body composition methodologies
to elucidate how these changes impact recurrence, prognosis, and mortality, and to provide clinicians with appropriate advice
regarding lifestyle recommendations in this growing sector of the population.

The Canadian Medical Association: From Profit to Equity | Open Medicine



Surgeries to Be Broadcast Live on the Internet



http://www.newswise.com/articles/view/592772/?sc=rsla&utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+NewswiseLatestNews+%28Newswise%3A+Latest+News%29&utm_content=Google+Reader

Forbes article: on fixing the healthcare system + other articles



http://www.forbes.com/sites/stevedenning/2012/08/20/another-non-solution-for-us-health-care-the-competition-tooth-fairy/

Anti-cancer regimens with multiple modes of action increase treatment effectiveness



http://www.news-medical.net/post.aspx?id=400cfe26-beed-4a99-8e4b-cdde9b6aefd1

More trial, less error - An effort to improve scientific studies



http://reut.rs/ShFG6y

Chemo-Resistant Ovarian Cancer | Medical News and Health Information



http://www.ivanhoe.com/channels/p_channelstory.cfm?storyid=29895

Trials | Abstract | Drug safety assessment in clinical trials: methodological challenges and opportunities



Open AccessReview

Drug safety assessment in clinical trials: methodological challenges and opportunities

Sonal Singh and Yoon K Loke

For all author emails, please log on.

Trials 2012, 13:138 doi:10.1186/1745-6215-13-138

Published: 20 August 2012

Abstract (provisional)

Randomized controlled trials are the principal means of establishing the efficacy of drugs. However pre-marketing trials are limited in size and duration and exclude high-risk populations. They have limited statistical power to detect rare but potentially serious adverse events in real-world patients. We summarize the principal methodological challenges in the reporting, analysis and interpretation of safety data in clinical trials using recent examples from systematic reviews. The principle challenges include the lack of an evidentiary gold standard, the limited statistical power of randomized controlled trials and resulting type 2 error, the lack of adequate ascertainment of adverse events and limited generalizability of safety trials that exclude high risk patients. We discuss potential solutions to these challenges. Evaluation of drug safety requires careful examination of data from heterogeneous sources. Meta-analyses of drug safety should include appropriate statistical methods and assess the optimal information size to avoid type 2 errors. They should evaluate outcome reporting biases and missing data to ensure reliable and accurate interpretation of findings. Regulatory and academic partnerships should be fostered to provide an independent and transparent evaluation of drug safety.

The complete article is available as a provisional PDF. The fully formatted PDF and HTML versions are in production.