9/1/08 Ovarian Cancer and Us OVARIAN CANCER and US Ovarian Cancer and Us

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Wednesday, September 24, 2008

Expenses May Cause Cancer Patients to Decline Clinical Trial Enrollment



Cancer Patients Decline Clinical Trial Enrollment

Clinical Care Options Oncology - Current Standards in Recurrent Ovarian Cancer



Clinical Care Options Oncology - Current Standards in Recurrent Ovarian Cancer

Clinical Care Options Oncology - Managing Ovarian Cancer Recurrence: Coupling Novel Therapeutics With Optimal Treatment Decisions



Clinical Care Options Oncology - Managing Ovarian Cancer Recurrence: Coupling Novel Therapeutics With Optimal Treatment Decisions

abstract: Paclitaxel maintenance chemotherapy following intraperitoneal chemotherapy for ovarian cancer



IngentaConnect Paclitaxel maintenance chemotherapy following intraperitoneal che...

Is Bowel Preparation Before Colonoscopy a Risky Business for The Kidney? CME



Is Bowel Preparation Before Colonoscopy a Risky Business for The Kidney?

Cochrane Systematic Review of Colorectal Cancer Screening



Cochrane Systematic Review of Colorectal Cancer Screening

"Conclusions:

........Controversy still surrounds the most effective screening modality for the detection of CRC in the population.[9–11] Clarification of whether FOBT (either guaiac or immunochemical), flexible sigmoidoscopy (alone or in combination with FOBT), or colonoscopy will provide the greatest benefits over the potential risks is required."

Medical News: ASTRO: Increased Stress a Continuing Problem for Some Cancer Survivors - in Meeting Coverage, ASTRO



Medical News: ASTRO: Increased Stress a Continuing Problem for Some Cancer Survivors - in Meeting Coverage, ASTRO from MedPage Today

Tuesday, September 23, 2008

Commentary: Practicing on the Tip of an Information Iceberg? Evidence of Underpublication of Registered Clinical Trials in Oncology



theoncologist.2008-0133v1.pdf (application/pdf Object)

Commentary: Publishing Cancer Clinical Trial Results: A Scientific and Ethical Imperative



theoncologist.2008-0168v1.pdf (application/pdf Object)

One in Five Cancer Clinical Trials Is Published: A Terrible Symptom--What's the Diagnosis?



One in Five Cancer Clinical Trials Is Published: A Terrible Symptom--What's the Diagnosis? -- Curt and Chabner, 10.1634/theoncologist.2008-0174 -- The Oncologist

ESTRO 27 AbstractBook



ESTRO27 AbstractBook.pdf (application/pdf Object)

Feasibility of Screening for Lynch Syndrome Among Patients With Colorectal Cancer



Feasibility of Screening for Lynch Syndrome Among Patients With Colorectal Cancer -- Hampel et al., 10.1200/JCO.2008.17.5950 -- Journal of Clinical Oncology

Conclusion:
One of every 35 patients with CRC has LS, and each has at least three relatives with LS; all of whom can benefit from increased cancer surveillance. For screening, IHC is almost equally sensitive as MSI, but IHC is more readily available and helps to direct gene testing. Limiting tumor analysis to patients who fulfill Bethesda criteria would fail to identify 28% (or one in four) cases of LS.

Monday, September 22, 2008

The Canadian Press: Newfoundland settles with 3 gynecologic oncologists



The Canadian Press: Williams says N.L. has reached deal that will keep doctors in province

e-Patients White Paper - how they can help us heal health care - Tom Ferguson and the e-patients scholars working group



e-Patients_White_Paper.pdf (application/pdf Object)

Clinical trials regulation -- how Canada compares -- Shuchman 179 (7): 635 -- Canadian Medical Association Journal



Clinical trials regulation -- how Canada compares -- Shuchman 179 (7): 635 -- Canadian Medical Association Journal

In Response: Markman - Neoadjuvant chemo for ovarian cancer: the debate reconsidered (discussion)



PowerSearch Document

full text (news source) What is the role of neoadjuvant chemo - areas of confusion in oncology



PowerSearch Document


"RECOMMENDATIONS

* Patients unable to tolerate aggressive cytoreductive surgery should undergo neoadjuvant chemotherapy first.

* Neoadjuvant chemotherapy should become a standard alternative approach to treating patients with stage IV ovarian cancer.

* Women with stage IIIC disease should be evaluated by a gynecologic oncologist to determine the likelihood of optimal cytoreducibility. If residual macroscopic disease would be expected with surgery alone, the patient should be offered the option of neoadjuvant chemotherapy."

Reference Guide

Therapeutic Agents Mentioned in This Article

Carboplatin

Cisplatin

Cyclophosphamide

Paclitaxel

free full text/abstract: Survival of HNPCC patients compared with sporadic colorectal cancer patients (Lynch Syndrome)



Abstract | Survival of hereditary non-polyposis colorectal cancer patients compared with sporadic colorectal cancer patients

Wednesday, September 17, 2008

Expert Opinion on Medical Diagnostics - p53: a molecular marker for the detection of cancer (reference to Li-Fraumeni Syndrome



Expert Opinion - Expert Opinion on Medical Diagnostics - 2(9):1013 - Summary

Just around the corner: rhetorics of progress and promise in genetic research - Journal of Public Understanding of Science



Just around the corner: rhetorics of progress and promise in genetic research -- Evans et al., 10.1177/0963662507078016 -- Public Understanding of Science

Modification of risk for subsequent cancer after female breast cancer by a family history of breast cancer



Modification of risk for subsequent cancer after f...[Breast Cancer Res Treat. 2008] - PubMed Result

Breast Cancer Res Treat. 2008 Sep;111(1):165-9. Epub 2007 Sep 27.Click here to read Links

Modification of risk for subsequent cancer after female breast cancer by a family history of breast cancer.

Division of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany. k.hemminki@dkfz.de

An increased risk of second primary cancers may depend on many reasons, including therapy for the first cancer and heritable causation. Population level data are not available exploring the risks of subsequent cancers after breast cancer considering a familial history of breast cancers. We used the nation-wide Swedish Family-Cancer Database to investigate such risks, based on 43,398 first invasive female breast cancers. Standardized incidence ratios (SIRs) were calculated for the second cancer after breast cancer using rates for first cancer as a reference. Many cancers at discordant sites were increased after breast cancer. SIRs for subsequent neoplasms in women who had a family history of breast cancer were increased for ovarian (2.0) and endometrial (1.8) cancers and for acute lymphoid leukemia (12.7) and myelofibrosis (9.4). The data suggest that the familial aggregation of breast and endometrial cancers may be explained by yet unidentified heritable causes. The remarkably high risks for second acute lymphoid leukemia and myelofibrosis, both characterized by chromosomal aberrations, in women with a family history of breast cancer may signal heritable defects in the ability to process DNA damage caused by ionizing radiation and chemotherapy.

Spontaneous nasal septal perforation with antiangiogenic Bevacizumab (Avastin) therapy



Spontaneous nasal septal perforation with antiangi...[Laryngoscope. 2008] - PubMed Result

Tuesday, September 16, 2008

2008 September: ESSO conference abstracts (EJSO - the Journal of Cancer surgery www.ejso.com)



binarydata.aspx (application/pdf Object)

Lymphadenectomy Improves 5-Year Survival Rates in Ovarian Cancer Patients: Presented at ESSO



"Since there might be some overlap between performing radical surgery and performing lymphadenectomy, maximal cytoreduction should remain the main objective in ovarian cancer surgery," Dr. Bergzoll concluded.


[Presentation title: The Therapeutic Role of Lymph Node Resection in Ovarian Cancer: Analysis of the Surveillance, Epidemiology, and End Results Database. Abstract 152]

2008 OCNA award winners: Carolyn Benivegna and Karen Mason



OCNA 2008 Award Winners! CONGRATULATIONS!

Cindy Melancon Spirit of Survivorship Award

Hailing from Novi, Michigan, Carolyn Benivegna will be this year’s recipient in honor of her persistent advocacy for promoting awareness for ovarian cancer. Carolyn is an ovarian cancer survivor and the founder of the Ovarian Cancer Alliance of Florida-Gulf Coast. She then moved to Michigan when she made a great impact by working with Governor Jennifer Granholm to declare September as Ovarian Cancer Awareness Month. Carolyn and her husband were also recognized by The Henry P. Tappan Society from the University of Michigan for establishing an endowed Ovarian Cancer Research Fund at UM.



The Voice for Ovarian Cancer Research Award

Taking the trip from Woodbury, NJ will be Karen Mason. After being diagnosed at the age of 49, she quickly discovered that getting involved in the ovarian cancer community was a great coping mechanism. Last Fall Karen was invited to be a member of the Dept of Defense’s Integration Panel where proposals are chosen for funding by the Department of Defense’s Ovarian Cancer Research Program. She also serves as a patient advocate for the Fox Chase Cancer Center ovarian SPORE as a full participating member of their Institutional Review Board evaluating consent forms for clinical trials. Karen is continually involved with NED (no evidence of disease) and is a part-time ICU nurse, wife and mother of two sons.

Level and direction of hope in cancer patients: an...[Support Care Cancer. 2008] - PubMed Result



Level and direction of hope in cancer patients: an...[Support Care Cancer. 2008] - PubMed Result

Pancreatic Resection of Isolated Metastases from N...[Ann Surg Oncol. 2008] - PubMed Result



Pancreatic Resection of Isolated Metastases from N...[Ann Surg Oncol. 2008] - PubMed Result

Combining a symptoms index with CA 125 to improve ...[Cancer. 2008] - PubMed Result



Combining a symptoms index with CA 125 to improve ...[Cancer. 2008] - PubMed Result

Survivorship: Next Steps to Take | Cancer.Net



Survivorship: Next Steps to Take | Cancer.Net

Informal Caregivers - Canadian Hospice Palliative Care Association



Informal Caregivers

Canadian Hospice Palliative Care Association



Home Page

Health System Facts - Percent of population that rates medical care received as very good or excellent, Ontario and by country, 2007



Health System Facts - Percent of population that rates medical care received as very good or excellent, Ontario and by country, 2007

Cost Effectiveness of Intraperitoneal Compared With Intravenous Chemotherapy for Women With Optimally Resected Stage III Ovarian Cancer: A Gynecologic Oncology Group Study -- Havrilesky et al. 26 (25)



Cost Effectiveness of Intraperitoneal Compared With Intravenous Chemotherapy for Women With Optimally Resected Stage III Ovarian Cancer: A Gynecologic Oncology Group Study -- Havrilesky et al. 26 (25)

BMJ Evidence Updates



BMJ Evidence Updates

Prognostic implication of endometriosis in clear c...[Gynecol Oncol. 2008] - PubMed Result



Prognostic implication of endometriosis in clear c...[Gynecol Oncol. 2008] - PubMed Result

Therapy-related myeloid leukemia. [Semin Oncol. 2008] - PubMed Result



Therapy-related myeloid leukemia. [Semin Oncol. 2008] - PubMed Result

Chromosomal instability in fallopian tube precurso...[Gynecol Oncol. 2008] - PubMed Result



Chromosomal instability in fallopian tube precurso...[Gynecol Oncol. 2008] - PubMed Result

abstract: Patient Navigation: State of the art or is it science?



Wiley InterScience :: JOURNALS :: Cancer

JCO.2008 Progress in Cancer Care: The Hope, the Hype, and the Gap Between Reality and Perception



Progress in Cancer Care: The Hope,
the Hype, and the Gap Between Reality
and Perception
JCO.2008.17.6198v1.pdf (application/pdf Object)

abstract:

JCO Early Release, published online ahead of print Sep 15 2008
Journal of Clinical Oncology, 10.1200/JCO.2008.17.6198


Progress in Cancer Care: The Hope, the Hype, and the Gap Between Reality and Perception

Leonard B. Saltz

Division of Solid Tumor Oncology, Department of Medicine, Memorial Sloan-Kettering Cancer Center, and Weill Medical College of Cornell University, New York, NY

Ovarian cancer drug trial reveals promising new treatment -Ovarian Cancer news-



Ovarian cancer drug trial reveals promising new treatment -Ovarian Cancer news-

Abstract: Breast vs ovarian cancer cells' molecular profile as a response to treatment with anticancer drugs Cisplatin, Carbo, Doxil, VP15 and Taxol



HighWire Press -- Medline Abstract

The Canadian Press: Hope, confusion in hunt for ovarian cancer tests; FDA watches field closely



The Canadian Press: Hope, confusion in hunt for ovarian cancer tests; FDA watches field closely

Genetic cancer risk assessment and counseling: recommendations of the National Society of Genetic Counselors.



Genetic cancer risk assessment and counseling: recommendations of the National Society of Genetic Counselors.

The Trajectory of Psychological Impast in BRCA 1/2 Genetic Testing - Does Time Heal?



HighWire Press -- Medline Abstract

Monday, September 15, 2008

2008 Abstract: Loss of DNA Mismatch Repair Protein hMSH6 in Ovarian Cancer is Histotype-Specific



HighWire Press -- Medline Abstract

2008 abstract: The Importance of CA125 Normalization During Neoadjuvant Chemotherapy Followed by Planned Delayed Surgical Debulking in Patients



HighWire Press -- Medline Abstract

2008 Factors influencing the implementation of clinical guidelines for health care professionals: a meta-review



1472-6947-8-38.pdf (application/pdf Object)

Researchers identify cancer-causing gene in many colon cancers



Researchers identify cancer-causing gene in many colon cancers

2008 abstract: Meaning in life assessed with the SMiLE: a comparison between a cancer patient and student sample (abstract)



SpringerLink - Journal Article

Clinical Care Options Oncology - Ovarian Cancer: Expert Recap



Clinical Care Options Oncology - Ovarian Cancer: Expert Recap

Welcome to the PeerView Press Website



Welcome to the PeerView Press Website

Public engagement in setting priorities in health care -- Bruni et al. 179 (1): 15 -- Canadian Medical Association Journal



Public engagement in setting priorities in health care -- Bruni et al. 179 (1): 15 -- Canadian Medical Association Journal

Is there any association between retroperitoneal lymphadenectomy and survival benefit in ovarian clear cell carcinoma patients? -- Suzuki et al. 19 (7): 1284 -- Annals of Oncology



Is there any association between retroperitoneal lymphadenectomy and survival benefit in ovarian clear cell carcinoma patients? -- Suzuki et al. 19 (7): 1284 -- Annals of Oncology

The Staging of Cancer: A Retrospective and Prospective Appraisal -- Greene and Sobin 58 (3): 180 -- CA: A Cancer Journal for Clinicians



The Staging of Cancer: A Retrospective and Prospective Appraisal -- Greene and Sobin 58 (3): 180 -- CA: A Cancer Journal for Clinicians

'Futile Care': What to Do When Your Patient Insists on Chemotherapy That Likely Won’t Help: - Cancer Network



'Futile Care': What to Do When Your Patient Insists on Chemotherapy That Likely Won’t Help: - Cancer Network

Don't let the silent killer get you by the ovaries



Don't let the silent killer get you by the ovaries

We Fought Cancer And Cancer Won



We Fought Cancer…And Cancer Won

2008 Current Oncology: Presentations from the Integrating Wellness into Cancer Care Conference



2008

Decision Making in Oncology: A Review of Patient Decision Aids to Support Patient Participation -- Stacey et al. 58 (5): 293 -- CA: A Cancer Journal for Clinicians



Decision Making in Oncology: A Review of Patient Decision Aids to Support Patient Participation -- Stacey et al. 58 (5): 293 -- CA: A Cancer Journal for Clinicians

2008 June (Stein study) ACS's Studies of Cancer Survivors



Stein.pdf (application/pdf Object)

Performance of BRCA1/2 Mutation Prediction Models in Asian Americans -- Kurian et al., 10.1200/JCO.2008.16.8310 -- Journal of Clinical Oncology



Performance of BRCA1/2 Mutation Prediction Models in Asian Americans -- Kurian et al., 10.1200/JCO.2008.16.8310 -- Journal of Clinical Oncology

Subdividing Ovarian and Peritoneal Serous Carcinom...[Am J Surg Pathol. 2008] - PubMed Result



Subdividing Ovarian and Peritoneal Serous Carcinom...[Am J Surg Pathol. 2008] - PubMed Result

A phase 2, randomized, double-blind, placebo-contr...[Gynecol Oncol. 2008] - PubMed Result



A phase 2, randomized, double-blind, placebo-contr...[Gynecol Oncol. 2008] - PubMed Result

Sensitivity to pertuzumab (2C4) in ovarian cancer models: cross-talk with estrogen receptor signaling -- Mullen et al. 6 (1): 93 -- Molecular Cancer Therapeutics



Sensitivity to pertuzumab (2C4) in ovarian cancer models: cross-talk with estrogen receptor signaling -- Mullen et al. 6 (1): 93 -- Molecular Cancer Therapeutics

Lost In Translation? FDA Believes That LabCorp’s Ovarian Cancer Early Detection Test (OvaSure) Lacks Adequate Clinical Validation « Libby’s H*O*P*E*



Lost In Translation? FDA Believes That LabCorp’s Ovarian Cancer Early Detection Test (OvaSure) Lacks Adequate Clinical Validation « Libby’s H*O*P*E*

advocacy9.pdf (application/pdf Object)



advocacy9.pdf (application/pdf Object)

Analysis of Survival by Tumor Response and Other Comparisons of Time-to-Event by Outcome Variables -- Anderson et al. 26 (24): 3913 -- Journal of Clinical Oncology



Analysis of Survival by Tumor Response and Other Comparisons of Time-to-Event by Outcome Variables -- Anderson et al. 26 (24): 3913 -- Journal of Clinical Oncology

Cancer.Net Podcasts | Cancer.Net



Cancer.Net Podcasts | Cancer.Net

When The Patient Can't Decide: Study Looks At Physician Perspectives On Surrogate Decision-making



When The Patient Can't Decide: Study Looks At Physician Perspectives On Surrogate Decision-making

Selected Combination Therapy with Sorafenib: A Review of Clinical Data and Perspectives in Advanced Solid Tumors -- Dal Lago et al., 10.1634/theoncologist.2007-0233 -- The Oncologist



Selected Combination Therapy with Sorafenib: A Review of Clinical Data and Perspectives in Advanced Solid Tumors -- Dal Lago et al., 10.1634/theoncologist.2007-0233 -- The Oncologist

Advocating a Treatment, but Denied Access to It | BlueRidgeNow.com | Times-News Online | Hendersonville, NC



Advocating a Treatment, but Denied Access to It | BlueRidgeNow.com | Times-News Online | Hendersonville, NC

Medical News: No Evidence of Benefit for Ovary Removal with Hysterectomy - in OB/GYN, General OB/GYN from MedPage Today



Medical News: No Evidence of Benefit for Ovary Removal with Hysterectomy - in OB/GYN, General OB/GYN from MedPage Today

PLoS Medicine - Next Stop, Don't Block the Doors: Opening Up Access to Clinical Trials Results



PLoS Medicine - Next Stop, Don't Block the Doors: Opening Up Access to Clinical Trials Results

NEJM -- Wellness Programs and Lifestyle Discrimination -- The Legal Limits



short abstract:

NEJM -- Wellness Programs and Lifestyle Discrimination -- The Legal Limits

Undertreatment of Cancer Patients With Chemotherapy Is a Global Concern -- Lyman 4 (3): 114 -- Journal of Oncology Practice



Undertreatment of Cancer Patients With Chemotherapy Is a Global Concern -- Lyman 4 (3): 114 -- Journal of Oncology Practice

Chemotherapy Dosing Strategies in the Obese, Elderly, and Thin Patient: Results of a Nationwide Survey -- Field et al. 4 (3): 108 -- Journal of Oncology Practice



Chemotherapy Dosing Strategies in the Obese, Elderly, and Thin Patient: Results of a Nationwide Survey -- Field et al. 4 (3): 108 -- Journal of Oncology Practice

Biocompare News - New Cancer Gene Discovered



Biocompare News - New Cancer Gene Discovered

Primary Care Physicians and Oncologists Are Players on the Same Team -- Grunfeld 26 (14): 2246 -- Journal of Clinical Oncology



Primary Care Physicians and Oncologists Are Players on the Same Team -- Grunfeld 26 (14): 2246 -- Journal of Clinical Oncology

Cancer often detected in patients with unprovoked venous thromboembolism - ASCO



Cancer often detected in patients with unprovoked venous thromboembolism - ASCO

Ovarian cancers may begin in fallopian tube- msnbc.com



Ovarian cancers may begin in fallopian tube- msnbc.com

Humour can play an essential role in the most serious healthcare settings



Humour can play an essential role in the most serious healthcare settings

Monday September 15th, 2008: CANO conference presentation - Survivors' Debate: The Past Decade in Ovarian Cancer



Survivors Debate: The Past Decade in Ovarian Cancer

Pamela J. West1, Sandi Pniauskas2, Carolyn Benivegna3. 1Rouge Valley Health System, Toronto,
ON, Canada, 2No Institution - patient, Whitby, ON, Canada, 3No Institution - patient,
Novi, MI, USA.

2008 Inquiry will hear cancer warning



telegraphjournal.com - Inquiry will hear cancer warning