Abstract
BACKGROUND:
Numerous
studies have focused on the association between MMP-12-82A>G
polymorphism and cancer risk, but produced inconsistent results.
Therefore, we performed a meta-analysis of case-control study to
evaluate the association of MMP-12-82A>G polymorphism and cancer
risk.
METHODS:
A
systematic literature search was conducted among PubMed, Web of
Science, Science Direct, China National Knowledge Infrastructure (CNKI)
and Wangfang databases updated on May 1st, 2015. Crude odds ratios (ORs)
with 95% confidence intervals (CIs) were used to evaluate the strength
of association between this polymorphism and cancer risk.
RESULTS:
A
total of seventeen case-control studies with 7,450 cases and 7,348
controls were identified and analyzed. Overall, there was no
statistically significant association between MMP-12-82A>G
polymorphism and increased risk of cancer under all genetic models.
Subgroup analysis by ethnicity observed that there is no strong
relationship between MMP-12-82A>G polymorphism and cancer risk among
Asian and European populations. Furthermore, stratified analysis based
on the source of control revealed no statistically significant
association between MMP-12-82A>G polymorphism and cancer risk either
in hospital-based or population-based studies. However, when we
stratified analysis based on cancer type, significant association was
found in ovarian cancer, but not in other types of cancer.
CONCLUSION:
This
meta-analysis suggests that MMP-12-82A>G polymorphism is not
significantly associated with overall cancer risk. However,
MMP-12-82A>G polymorphism may increase the susceptibility to ovarian
cancer.
0 comments :
Post a Comment
Your comments?
Note: Only a member of this blog may post a comment.