Apr 2011 Gastroenterology & Endoscopy News - Henry Lynch, MD, Delivers Keynote Address on Lynch Syndrome & Gary H. Hoffman, MD

Note: requires registration (free) to view, discusses sporadic cancer/s, BRAF mutation plus EPCAM mutations, treatment responses etc:

"EPCAM mutation carriers may have phenotypic features that differ from carriers of MSH2 mutations, namely, an almost exclusive expression of site-specific CRC and an absence of extracolonic cancers. “This is really new, and more information is needed on this,” he said".
"Of therapeutic interest, patients with MSI-high tumors may respond differently to chemotherapy."

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"Henry Lynch, MD, Delivers Keynote Address on Lynch Syndrome

Doctor Who First Described the Syndrome Offers Guidance on Management of Inherited CRC

by Caroline Helwick

San Francisco—Microsatellite instability (MSI) is an important factor in the evaluation of Lynch syndrome colorectal cancer (CRC) and should be part of the workup of these patients, according to Henry Lynch, MD, who defined the syndrome and gave the keynote lecture at the 2011 American Society of Clinical Oncology Gastrointestinal Cancers Symposium....."