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Tuesday, April 17, 2012

Diffusion-weighted Imaging Study in Cancer of the Ovary - Full Text View - ClinicalTrials.gov



Diffusion-weighted Imaging Study in Cancer of the Ovary - Full Text View - ClinicalTrials.gov

Diffusion-weighted Imaging Study in Cancer of the Ovary (DISCOVAR)
This study is not yet open for participant recruitment.
Verified March 2012 by Institute of Cancer Research, United Kingdom


First Received on November 18, 2011.   Last Updated on March 30, 2012   History of Changes
Sponsor: Institute of Cancer Research, United Kingdom
Collaborators: Cancer Research UK
Royal Marsden NHS Foundation Trust
Cambridge University Hospitals NHS Foundation Trust
Imperial College Healthcare NHS Trust
Northumbria Healthcare NHS Foundation Trust
Information provided by (Responsible Party): NdeSouza, Institute of Cancer Research, United Kingdom
ClinicalTrials.gov Identifier: NCT01505829
  Purpose
This project seeks to develop a quantitative imaging biomarker for evaluating and monitoring treatment response in ovarian cancer metastases and assess its potential in monitoring treatment response. This will involve standardising DW-MRI for the abdomen and pelvis across multiple centres and platforms, assessing reproducibility of the measurement in patients planned for neoadjuvant chemotherapy and assessing its utility as an early response biomarker in patients with platinum-sensitive relapse due to receive therapy with carboplatin. Scanning measurements will be correlated with histopathological markers in tumour samples in order to link the biomarker with response mechanisms.

Condition
Ovarian Cancer
Peritoneal Metastases

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Assessing Treatment Response of Peritoneal Metastases in Ovarian Cancer Using Diffusion Weighted Magnetic Resonance Imaging.

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