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Preoperative diagnosis of metastatic ovarian cancer is related to origin of primary tumor - Guerriero - 2012 - Ultrasound in Obstetrics & Gynecology
Abstract
Objective
To
describe the gray-scale and color Doppler ultrasound features as well
as some clinical and biochemical features of metastatic ovarian tumors
according to the origin of the primary tumor in a large study
population,
Methods
This
was a retrospective analysis of 116 masses in 92 patients (mean age, 51
years) evaluated and treated at three European university centers for a
metastatic tumor in the ovary. All patients had undergone transvaginal
color Doppler ultrasound according to a standardized protocol prior to
surgery and tumor removal. Ultrasound features analyzed were
bilaterality, tumor volume, morphologic gray-scale appearance and color
score. CA 125 was also recorded.
Results
Primary tumor histological diagnosis was as follows: colon-sigmoid (n = 32), stomach (n = 28), breast (n = 20), uterus (n = 17), lymphoma (n = 4), liver-pancreas-biliary tract (n = 4) and miscellaneous (n
= 11). There were no differences in age, menopausal status or CA 125
values according to origin of primary tumor. Bilaterality was
significantly more frequent in stomach metastases (56%) in comparison
with colon-sigmoid and liver-pancreas-biliary tract metastases (18.5%
and 0%, respectively, P < 0.05). Median tumor volume was significantly lower in breast metastases (33.5 mL) compared with other metastases (P
< 0.05) except stomach metastases and metastatic tumors from the
miscellaneous group. Ovarian metastases from breast cancers were
significantly more frequently solid in comparison to stomach, colorectal
and uterine cancer metastases (95.0% vs. 60.8%, 46.8% and 70.6%,
respectively, P < 0.05), and tended to appear moderately or
highly vascularized. There were no differences in color score among all
groups, although the percentage of masses with abundant color was high
(50–82%).
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