OVARIAN CANCER and US: CA 125

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Showing posts with label CA 125. Show all posts
Showing posts with label CA 125. Show all posts

Sunday, April 29, 2012

paywalled - Preoperative diagnosis of metastatic ovarian cancer is related to origin of primary tumor - Guerriero - 2012 - Ultrasound in Obstetrics & Gynecology - Wiley Online Library



Preoperative diagnosis of metastatic ovarian cancer is related to origin of primary tumor - Guerriero - 2012 - Ultrasound in Obstetrics & Gynecology

Abstract

Objective

To describe the gray-scale and color Doppler ultrasound features as well as some clinical and biochemical features of metastatic ovarian tumors according to the origin of the primary tumor in a large study population,

Methods

This was a retrospective analysis of 116 masses in 92 patients (mean age, 51 years) evaluated and treated at three European university centers for a metastatic tumor in the ovary. All patients had undergone transvaginal color Doppler ultrasound according to a standardized protocol prior to surgery and tumor removal. Ultrasound features analyzed were bilaterality, tumor volume, morphologic gray-scale appearance and color score. CA 125 was also recorded.

Results

Primary tumor histological diagnosis was as follows: colon-sigmoid (n = 32), stomach (n = 28), breast (n = 20), uterus (n = 17), lymphoma (n = 4), liver-pancreas-biliary tract (n = 4) and miscellaneous (n = 11). There were no differences in age, menopausal status or CA 125 values according to origin of primary tumor. Bilaterality was significantly more frequent in stomach metastases (56%) in comparison with colon-sigmoid and liver-pancreas-biliary tract metastases (18.5% and 0%, respectively, P < 0.05). Median tumor volume was significantly lower in breast metastases (33.5 mL) compared with other metastases (P < 0.05) except stomach metastases and metastatic tumors from the miscellaneous group. Ovarian metastases from breast cancers were significantly more frequently solid in comparison to stomach, colorectal and uterine cancer metastases (95.0% vs. 60.8%, 46.8% and 70.6%, respectively, P < 0.05), and tended to appear moderately or highly vascularized. There were no differences in color score among all groups, although the percentage of masses with abundant color was high (50–82%).

Conclusions

Ovarian metastases derived from breast cancers tend to be small, solid and vascularized; they seem to be the only ovarian metastases whose primary tumor origin can be suspected by ultrasonography preoperatively. Color score does not seem to help suspect the origin of the primary tumor.

Monday, July 18, 2011

Proteomic biomarkers in combination with CA 125 for detection of epithelial ovarian cancer using prediagnostic serum samples from the prostate, lung, colorectal, and ovarian (PLCO) cancer screening trial



RESULTS:

CA 125 levels were elevated (≥35 U/mL) in 61.5% of 65 patients who had CA 125 data available from samples that were collected <12 months before cancer diagnosis; however, levels of the additional 7 biomarkers were not different between cases and the 3 control groups individually or combined. Two panels that combined CA 125 and the 7 biomarkers failed to improve the sensitivity of CA 125 alone.

CONCLUSIONS:

In contrast to earlier findings from analyzes of postdiagnostically collected sera, the addition of 7 biomarkers to CA 125 did not improve sensitivity for preclinical diagnosis beyond CA 125 alone.

Saturday, May 22, 2010

podcast: CA-125 Change Over Time Shows Promise as Screening Tool for Early Detection of Ovarian Cancer



CA-125 Change Over Time Shows Promise as Screening Tool for Early Detection of Ovarian Cancer

Blood test currently approved to find recurrence full of new possibility; invasive, high-grade disease uncovered at curable stage
MD Anderson News Release 05/20/10

Wednesday, May 05, 2010

CA 125 Algorithm for the Early Detection of Ovarian Cancer - Full Text View - ClinicalTrials.gov



Note: still recruiting as of Jan 2010 Official Title: Use of the CA 125 Algorithm for the Early Detection of Ovarian Cancer in Low Risk Women