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Abstract
Epithelial ovarian cancer
(EOC) is a complex disease, with multiple histological subtypes
recognized. There have been major advances in the understanding of the
cellular and molecular biology of this human malignancy, however the
survival rate of women with EOC has changed little since
platinum-based-treatment was introduced more than 30 years ago. Since
2006, an increasing number of studies have indicated an essential role
for microRNAs (miRNAs) in ovarian-cancer tumorigenesis. Several miRNA profiling studies have shown that they associate with different aspects of ovarian cancer
(tumor subtype, stage, histological grade, prognosis, and therapy
resistance) and pointed to a critical role for miRNAs in the
pathogenesis and progression of EOC. In this review, we discuss the
current data concerning the accumulating evidence of the modulated
expression of miRNAs in EOC, their role in diagnosis, prognosis, and
prediction of response to therapy. Given the heterogeneity of this
disease, it is likely that increases in long-term survival might be also
achieved by translating the recent insights of miRNAs involvement in
EOC into novel targeted therapies that will have a major impact on the
management of ovarian cancer.
See also prior blog posts on related topic:
(abstract) FOCUS REVIEW
MicroRNAs in ovarian carcinomas
Neetu Dahiya1 and Patrice J Morin1,2
1 Laboratory of Cellular and Molecular Biology, National Institute on Aging, NIH Biomedical Research Center, 251 Bayview Boulevard, Suite 100, Room 6C228, Baltimore, Maryland 21224, USA
2 Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
See also prior blog posts on related topic:
Thursday, February 04, 2010
MicroRNAs in ovarian carcinomas -- Dahiya and Morin 17 (1): F77 -- Endocrine-Related Cancer
(abstract) FOCUS REVIEW
MicroRNAs in ovarian carcinomas
Neetu Dahiya1 and Patrice J Morin1,2
1 Laboratory of Cellular and Molecular Biology, National Institute on Aging, NIH Biomedical Research Center, 251 Bayview Boulevard, Suite 100, Room 6C228, Baltimore, Maryland 21224, USA
2 Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
Thursday, December 10, 2009
MicroRNAs in Ovarian Carcinomas
Medline Abstract
N Dahiya, Lab Cell Molec Biol, NIH, Baltimore, United States. |  | |||||||||||
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| The molecular mechanisms involved in epithelial ovarian cancer initiation and progression are just beginning to be elucidated. In particular, it has become evident that microRNAs (miRNAs), a class of molecules that post-trancriptionally regulates gene expression, play a major role in ovarian tumorigenesis. Several miRNA profiling studies have identified changes in miRNA patterns that take place during ovarian cancer development. While most deregulated miRNAs are down-regulated in cancer, and may therefore act as tumor suppressors, others are elevated and may represent novel oncogenes in this disease. A number of miRNAs identified as aberrantly expressed in ovarian carcinoma have been shown to have important functional roles in cancer development and may therefore represent targets for therapy. In addition, some of the miRNA patterns may have prognostic significance. The identification of functional targets represents a major hurdle in our understanding of miRNA function in ovarian carcinoma, but significant progress is being made. It is hoped that a better understanding of the miRNA expression and roles in ovarian cancer may provide new avenues for the detection, diagnosis, and therapy of this deadly disease. PMID: 19903743 | ||||||||||||
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