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abstract
Highlights
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- Surgeons should consider the possibility of malignancy in patients with Lynch syndrome who are undergoing risk-reducing surgery.
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- Surgeons should consider pre-operative testing and sending operative specimens for frozen pathology to determine the need for staging.
Objective:
The primary aim of this study was to determine the prevalence of occult
gynecologic malignancy at the time of risk reducing surgery in patients
with Lynch Syndrome. A secondary aim was to determine the prevalence of
occult gynecologic malignancy at the time of surgery for
non-prophylactic indications in patients with Lynch Syndrome.
Methods:
A retrospective review of an Inherited Colorectal Cancer Registry found
76 patients with Lynch syndrome (defined by a germline mutation in a
DNA mismatch repair gene) or hereditary nonpolyposis colorectal cancer
(HNPCC) (defined by Amsterdam criteria) who had undergone hysterectomy
and/or salpingo-oophorectomy for a prophylactic or non-prophylactic
indication. Indications for surgery and the prevalence of cancer at the
time of each operation were reviewed.
Results: 24 of
76 patients underwent prophylactic hysterectomy and/or bilateral
salpingo-oophorectomy for Lynch syndrome or HNPCC. In 9 of these
patients, a benign indication for surgery was also noted. 4 of 24
patients (17%, 95% CI = 5-38%) were noted to have cancer on final
pathology. 20 of 76 patients (26%) undergoing operative management for
any indication were noted to have occult malignancy on final pathology.
Conclusions:
Patients should be counseled about the risks of finding gynecologic
cancer at the time of prophylactic or non-prophylactic surgery for Lynch
syndrome and HNPCC, and the potential need for additional surgery.
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