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science news
Nov. 6, 2013 — Results of an EORTC study published in Cancer point out the prognostic value of baseline recorded health-related quality of life for survival for eleven types of cancer: brain, breast, colorectal, esophageal, head and neck, lung, melanoma, ovarian, pancreatic, prostate, and testicular cancer. For each cancer site, at least one health-related quality of life parameter provided additional prognostic information over and above the clinical and sociodemographic variables.....
"nausea and vomiting for ovarian cancer"
abstract
A global analysis of multitrial data investigating quality of life and symptoms as prognostic factors for survival in different tumor sites
BACKGROUND
The
objective of this study was to examine the prognostic value of baseline
health-related quality of life (HRQOL) for survival with regard to
different cancer sites using 1 standardized and validated patient
self-assessment tool.
METHODS
In
total, 11 different cancer sites pooled from 30 European Organization
for Research and Treatment of Cancer (EORTC) randomized controlled
trials were selected for this study. For each cancer site, univariate
and multivariate Cox proportional hazards modeling was used to assess
the prognostic value (P < .05) of 15 HRQOL parameters using
the EORTC Core Quality of Life Questionnaire (QLQ-C30). Models were
adjusted for age, sex, and World Health Organization performance status
and were stratified by distant metastasis.
RESULTS
In
total, 7417 patients completed the EORTC QLQ-C30 before randomization.
In brain cancer, cognitive functioning was predictive for survival; in
breast cancer, physical functioning, emotional functioning, global
health status, and nausea and vomiting were predictive for survival; in
colorectal cancer, physical functioning, nausea and vomiting, pain, and
appetite loss were predictive for survival; in esophageal cancer,
physical functioning and social functioning were predictive for
survival; in head and neck cancer, emotional functioning, nausea and
vomiting, and dyspnea were predictive for survival; in lung cancer,
physical functioning and pain were predictive for survival; in melanoma,
physical functioning was predictive for survival; in ovarian cancer,
nausea and vomiting were predictive for survival; in pancreatic cancer,
global health status was predictive for survival; in prostate cancer,
role functioning and appetite loss were predictive for survival; and, in
testis cancer, role functioning was predictive for survival.
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