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abstract
Progesterone
and its receptor, progesterone receptor (PGR), have been widely studied
for their roles in the onset and development of ovarian cancer.
Although numerous epidemiological studies have focused on the
association of PGR PROGINS and +331G/A polymorphisms with ovarian cancer
susceptibility, presently, available results remain controversial, in
part due to low sample sizes. Thus, a meta-analysis is required to
evaluate this association. A literature search of PubMed, Embase, Web of
Science, CNKI, and CBM databases was performed to retrieve eligible
studies published before August 15, 2013. Summary odds ratios (ORs) with
95 % confidence intervals (CIs) were used to evaluate the strength of
this association. All analyses were done using STATA 12.0 software
(Stata Corp., College Station, TX, USA). Seventeen case-control studies
with a total of 6,365 cases and 9,998 controls were identified. While no
statistically significant association between the PROGINS allele and
ovarian cancer risk was found in an overall analysis, a stratified
analysis revealed that for Caucasians, never-oral contraceptive (OC)
users, and serous tumor patients, there were statistically significant
ORs for ovarian cancer risk associated with the mutated PROGINS allele.
No significant association, however, between the +331G/A polymorphism
and ovarian cancer susceptibility was observed in the overall analyses
and subgroup analyses based on ethnicity and histological type. This
meta-analysis provides evidence that the PROGINS allele occurs more
frequently in ovarian cancer patients and especially in non-OC users and
serous cancer patients, indicating that PROGINS may be a risk modifier.
No significant association between the +331G/A polymorphism and ovarian
cancer was found, even in stratified analyses by ethnicity and
histological type. More detailed and well-designed studies are still
needed to confirm the role of the PROGINS allele in ovarian cancer
development.
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