The
aim of this study was to compare multidetector CT (MDCT), MRI, and FDG
PET/CT imaging for the detection of peritoneal carcinomatosis (PC) in ovarian cancer.
PATIENTS AND METHODS:
Fifteen women with ovarian cancer
and suspected PC underwent MDCT, MRI, and FDG PET/CT, shortly before
surgery. Nine abdominopelvic regions were defined according to the
peritoneal cancer
index. We applied lesion size scores on MDCT and MR and measured FDG
PET/CT standard uptake. We blindly read MDCT, MR, and PET/CT before
joint review and comparison with histopathology. Receiver operating
characteristics analysis was performed.
RESULTS:
Ten
women had PC (67%). Altogether, 135 abdominopelvic sites were compared.
Multidetector CT, MRI, and FDG PET/CT had a sensitivity of 96%, 98%,
and 95%, and specificity was 92%, 84%, and 96%, respectively.
Corresponding receiver operating characteristics area was 0.94, 0.90,
and 0.96, respectively, without any significant differences between them
(P = 0.12). FDG PET/CT detected supradiaphragmatic disease in 3 women
(20%) not seen by MDCT or MRI.
CONCLUSIONS:
Although
MRI had the highest sensitivity and FDG PET/CT had the highest
specificity, no significant differences were found between the 3
techniques. Thus, MDCT, as the fastest, most economical, and most widely
available modality, is the examination of choice, if a stand-alone
technique is required. If inconclusive, PET/CT or MRI may offer
additional insights. Whole-body FDG PET/CT may be more accurate for
supradiaphragmatic metastatic extension.
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