OBJECTIVES:
Inflammation is a common feature of epithelial ovarian cancer
(EOC), and measurement of plasma markers of inflammation might identify
candidate markers for use in screening or presurgical evaluation of
patients with adnexal masses.
METHODS:
Plasma
specimens from cohorts of 100 patients with advanced EOC (AJCC Stage
III and IV), 50 patients with early stage EOC (Stage I and II), and 50
patients with benign surgical conditions were assayed for concentrations
of multiple cytokines, toll-like receptor agonists, and vascular growth
factors via ELISA and electrochemiluminescence. Immune proteins were
then analyzed for association with EOC. Differences in plasma protein
levels between benign, early, and advanced EOC patient groups were
assessed with and without adjustment for plasma cancer antigen 125 (CA-125) levels.
RESULTS:
Out
of 23 proteins tested, six-including interferon gamma (IFNγ),
interleukin 6 (IL-6), IL-8, IL-10, tumor necrosis factor alpha (TNFα),
and placental growth factor (PlGF)-were univariately associated with EOC
(all p<0.005), and one-IL-6-was associated with early stage EOC
(p<0.0001). Heat shock protein 90kDa beta member 1 (HSP90B1, gp96)
was associated with EOC and early stage EOC with borderline statistical
significance (p=0.039 and p=0.026, respectively). However, when adjusted
for (CA-125), only HSP90B1 independently predicted EOC (p=0.008), as
well as early stage EOC (p=0.014).
CONCLUSIONS:
Multiple
plasma cytokines, including IFNγ, IL-6, IL-8, IL-10, TNFα, PlGF, and
HSP90B1 are associated with EOC. Of these, HSP90B1 is associated with
EOC independent from the biomarker CA-125.
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