Paper/Letter/Author's Response: 2 Types of Ovarian Cortical Inclusion Cysts: Proposed Origin and Possible Role in Ovarian Serous Carcinogenesis

open access - Letter:
 

The above publication is very interesting and deals with an important topic, that is, the source of high-grade serous ovarian carcinomas. The authors propose that all of these highly malignant tumors originate from oviductal fimbriae, or from ovarian cortical inclusion cysts (CICs) that are derived from fimbriae, rather than from CICs derived from ovarian surface epithelium (OSE). Several points in the publication require clarification before this conclusion can be accepted:......

Author's Response: (open access)   To the Editor: We appreciate Dr Auersperg's letter regarding our paper as it gives us the opportunity to address and clarify issues which she raises. As we understand from her letter, Dr Auersperg primarily takes issue with the view that all high-grade ovarian serous carcinomas are derived from fallopian tube-type epithelium. Although we do subscribe to this view, this was not the primary aim of our study. The specific aim was to try to characterize the nature and presumed origin of ovarian cortical inclusion cysts (CICs) because they have been proposed to be the source of these ovarian carcinomas..... Original Article: Two Types of Ovarian Cortical Inclusion Cysts: Proposed Origin and Possible Role in Ovarian Serous Carcinogenesis Banet, Natalie; Kurman, Robert J.   International Journal of Gynecological Pathology