Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: the challenge ahead Ovarian Cancer and Us OVARIAN CANCER and US Ovarian Cancer and Us

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Monday, August 17, 2015

Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: the challenge ahead



open access
 About the Journal
Carcinogenesis: Integrative Cancer Research is a multi-disciplinary journal that brings together all the varied aspects of research that will ultimately lead to the prevention of cancer in man.....

Introduction

Cancer is a burden on humanity and among the leading causes of morbidity and mortality worldwide, with ~14 million new cases and 8.2 million cancer-related deaths in 2012 (1). In general, both genetic and environmental factors play a role in an individual’s cancer susceptibility (2,3), so there has been a long-standing emphasis on avoidable ‘lifestyle’ factors (i.e. those that can be modified to reduce the incidence of the disease) and a parallel focus on exogenous chemical exposures (e.g. agricultural, occupational and so on) (4). But advances in our understanding of the complexity of cancer biology have resulted in serious critiques of current risk assessment practices related to exogenous exposures (5) along with calls for an expanded focus on research that will allow us to evaluate the (potentially carcinogenic) effects of in-utero exposures and low-level exposures to combinations of chemicals that occur throughout our lifetime (6,7).....

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