open access
About the Journal
Carcinogenesis: Integrative Cancer Research is a
multi-disciplinary journal that brings together all the varied aspects
of research that will ultimately lead to the prevention of cancer in
man.....
Introduction
Cancer is a burden on humanity and among the leading causes of morbidity and mortality worldwide, with ~14 million new cases
and 8.2 million cancer-related deaths in 2012 (
1). In general, both genetic and environmental factors play a role in an individual’s cancer susceptibility (
2,
3),
so there has been a long-standing emphasis on avoidable ‘lifestyle’
factors (i.e. those that can be modified to reduce
the incidence of the disease) and a parallel focus
on exogenous chemical exposures (e.g. agricultural, occupational and so
on) (
4). But advances in our understanding of the complexity of cancer biology have resulted in serious critiques of current risk
assessment practices related to exogenous exposures (
5) along with calls for an expanded focus on research that will allow us to evaluate the (potentially carcinogenic) effects
of
in-utero exposures and low-level exposures to combinations of chemicals that occur throughout our lifetime (
6,
7).....
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