TP53 mutations, tetraploidy and homologous recombination repair defects in early stage high-grade serous ovarian cancer

open access (somewhat technical - worth reading)

Conclusions 

.....Despite heterogeneity in somatic sequence variations, CNAs and structural variations, none of these somatic genotypes appears to be associated with clinical outcome. Only stage appears to be strongly linked to patient survival, as six of eight patients with stage I HGS ovarian carcinomas are still alive (median follow-up 101 months), whereas only two of eight with stage 2 disease are still alive (median follow-up 79 months). Collectively, these observations provide new insight into the biology and likely pathogenesis of early stage HGS ovarian cancer.