Ovarian cancer in BRCA1/2 mutation carriers: The impact of mutation position and family history on the cancer risk

abstract
 

Highlights

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The impact of mutation position and family history on ovarian cancer (OC) risks was assessed.

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In BRCA1 families women with a mutation within the OCCR region have higher OC risks.

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In BRCA2 families, mutation position did not significantly affect the OC risk.

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In BRCA2 families, a family history including only OC presented a strong impact on OC risk.