|
|
|
|
|
|
|
|
1) New Articles -- EvidenceUpdates
2) open access full text
Abstract
BACKGROUND: Hyperbaric oxygen has been used as a therapy for patients experiencing chronic intestinal syndromes after pelvic radiotherapy for decades, yet the evidence to support the use of this therapy is based almost exclusively on non-randomised studies. We aimed to provide conclusive results for the clinical benefits of hyperbaric oxygen in patients with chronic bowel dysfunction after radiotherapy for pelvic malignancies.
INTERPRETATION: We found no evidence that patients with radiation-induced chronic gastrointestinal symptoms, including those patients with rectal bleeding, benefit from hyperbaric oxygen therapy. These findings contrast with evidence used to justify current practices, and more level 1 evidence is urgently needed.
Glover M, Smerdon GR, Andreyev HJ, et al. Hyperbaric oxygen for patients with chronic bowel dysfunction after pelvic radiotherapy (HOT2): a randomised, double-blind, sham-controlled phase 3 trial. Lancet Oncol. 2015 Dec 15. pii: S1470-2045(15)00461-1. doi: 10.1016/S1470-2045(15)00461-1. (Original) PMID: 26703894 | ||
Read Abstract Read Comments |
0 comments :
Post a Comment
Your comments?
Note: Only a member of this blog may post a comment.