abstract
FDR = first degree relatives
FINDINGS:
One-time
screening at age 50 resulted in a LE gain of 3.9 days for the primary
BRCA2 cohort, and a gain of 5.8 days for those with BRCA2 and one FDR.
Annual screening resulted in LE loss of 12.9 days for the primary cohort
and 1.3 days for BRCA2 carriers with 1 FDR, but resulted in 20.6 days
gained for carriers with 2 FDRs and 260 days gained for those with 3
FDRs. For patients with ≥ 3 FDRs, annual screening starting at an
earlier age (i.e. 35-40) was optimal.
INTERPRETATION:
Among
BRCA2 mutation carriers, aggressive screening regimens may be
ineffective unless additional indicators of elevated risk (e.g., 2 or
more FDRs) are present. More clinical studies are needed to confirm
these findings.
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