Review Article Hereditary Syndromes Manifesting as Endometrial Carcinoma: How Can Pathological Features Aid Risk Assessment? Ovarian Cancer and Us OVARIAN CANCER and US Ovarian Cancer and Us

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Saturday, March 12, 2016

Review Article Hereditary Syndromes Manifesting as Endometrial Carcinoma: How Can Pathological Features Aid Risk Assessment?



 open access
 Synchronous ovarian and endometrial tumors have also been connected to MSI. The most common pattern is that of endometrioid carcinomas in both the endometrium and ovary [50–52].

(reference):
A. S. Bats, H. Roussel, C. Narjoz et al., “Microsatellite instability analysis for the screening of synchronous endometrial and ovarian cancer in lynch syndrome,” Anticancer Research, vol. 33, no. 9, pp. 3977–3981, 2013. View at Google Scholar
Compared with sporadic cancer, the incidence of synchronous endometrial and ovarian cancer in LS is higher
Table 1


Syndrome Incidence in general population Lifetime risk of developing endometrial carcinoma Most common sentinel tumor in women (%) Germline gene mutation Associated malignancies  
Lynch syndrome or hereditary nonpolyposis syndrome (HNPCC) 1 in 300 to 1 in 500 40%–60% Endometrial carcinoma (50%) MLH1, MSH2, MSH6, PSM2, EPCAM Endometrial, ovarian, gastric, breast,
intestinal, pancreatic, urinary tract, renal, and bile duct carcinoma

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