Review Article Hereditary Syndromes Manifesting as Endometrial Carcinoma: How Can Pathological Features Aid Risk Assessment?

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 Synchronous ovarian and endometrial tumors have also been connected to MSI. The most common pattern is that of endometrioid carcinomas in both the endometrium and ovary [50–52].

(reference):
A. S. Bats, H. Roussel, C. Narjoz et al., “Microsatellite instability analysis for the screening of synchronous endometrial and ovarian cancer in lynch syndrome,” Anticancer Research, vol. 33, no. 9, pp. 3977–3981, 2013. View at Google Scholar

Compared with sporadic cancer, the incidence of synchronous endometrial and ovarian cancer in LS is higher

Table 1

Syndrome	Incidence in general population	Lifetime risk of developing endometrial carcinoma	Most common sentinel tumor in women (%)	Germline gene mutation	Associated malignancies
Lynch syndrome or hereditary nonpolyposis syndrome (HNPCC)	1 in 300 to 1 in 500	40%–60%	Endometrial carcinoma (50%)	MLH1, MSH2, MSH6, PSM2, EPCAM	Endometrial, ovarian, gastric, breast, intestinal, pancreatic, urinary tract, renal, and bile duct carcinoma