|
|
|
|
|
|
|
|
Our data support the policy of histotype-specific Lynch syndrome screening in ovarian carcinoma confined to endometrioid and clear cell carcinomas
abstract (repeat)
Significant frequency of MSH2/MSH6 abnormality in ovarian endometrioid carcinoma supports histotype-specific Lynch syndrome screening in ovarian carcinomas
Aims
Lynch
syndrome screening in ovarian carcinoma is controversial. The aim of
this study was to assess the frequency of deficient mismatch repair
(dMMR) protein in a retrospective cohort enriched for non-high-grade
serous carcinomas and its association with outcome within histological
types.
Methods and results
Tissue
microarrays representing 612 ovarian carcinomas were tested for
mismatch repair proteins (MLH1, PMS2, MSH2, and MSH6) by
immunohistochemistry. dMMR was detected in 13.8% of endometrioid and
2.4% of clear cell carcinomas, but not in other histological types.
Within endometrioid carcinomas, 11 of 25 dMMR cases showed abnormal
MLH1/PMS2, 10 cases showed abnormal MSH2/MSH6, and four cases showed
only abnormal MSH6, indicating that at least 7.7% of endometrioid
carcinomas have dMMR probably related to Lynch syndrome. The four dMMR
clear cell carcinomas showed abnormal MSH2/MSH6 in three cases and only
abnormal MSH6 in one case, all probably related to Lynch syndrome.
Within endometrioid carcinomas, dMMR was significantly associated with
age <50 years, synchronous endometrial endometrioid carcinoma, a
higher CA125 level at diagnosis, higher FIGO grade, absence of ARID1A,
and at least 20 CD8-positive intraepithelial lymphocytes per high-power
field, but was not associated with cancer-specific death. Age <50
years, higher CA125 levels at diagnosis and at least 20 CD8-positive
intraepithelial lymphocytes per high-power field remained significant
after adjustment for multiple testing, but their sensitivity for
identifying dMMR remained insufficient.
Conclusion
Our
data support the policy of histotype-specific Lynch syndrome screening
in ovarian carcinoma confined to endometrioid and clear cell carcinomas.
0 comments :
Post a Comment
Your comments?
Note: Only a member of this blog may post a comment.