Surgical management of cardiophrenic lymph nodes in patients with advanced ovarian cancer Ovarian Cancer and Us OVARIAN CANCER and US Ovarian Cancer and Us

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Thursday, March 17, 2016

Surgical management of cardiophrenic lymph nodes in patients with advanced ovarian cancer



abstract
 

Highlights

Importance of complete resection in primary ovarian cancer
Excision of suspicious cardiophrenic lymph nodes via a transdiaphragmatic approach
Feasibility, management and complications of resection

Abstract

Objective

Debulking surgery for advanced ovarian cancer does not routinely include opening of the thorax. Even systematic lymphadenectomy does not commonly extend to lymph nodes above the diaphragm. We evaluated the outcome of systematic resection of suspicious cardiophrenic lymph nodes detected on preoperative CT-scan in patients with advanced epithelial ovarian cancer (EOC).

Methods

Single-center, prospective series of 196 consecutive patients with EOC undergoing primary debulking surgery between June 2013 and June 2015. Suspicious cardiophrenic lymph nodes were defined as ≥ 10 mm on the short axis diagnosed in pre-operative CT-scan and were removed if intra-abdominal debulking resulted in complete resection or residual tumor < 10 mm and the patients' performance status allowed this additional procedure. Removal of suspicious cardiophrenic lymph nodes was performed via a trans-diaphragmatic approach.

Results

Thirty (15%) out of 196 EOC patients had radiologically suspicious cardiophrenic lymph nodes ≥ 10 mm and complete resection or residual tumor < 10 mm. Twenty-seven out of the thirty patients had at least one confirmed metastatic cardiophrenic lymph node. Metastatic cardiophrenic lymph nodes were associated with extensive intra-abdominal tumor spread in the upper abdomen.

Conclusions

Patients with suspicious cardiophrenic lymph nodes detected by preoperative CT-scan had histologically confirmed metastasis in 90% of cases. The surgical procedure is feasible without major complications if performed by experienced gyneco-oncologists. The prognostic value of this procedure should be evaluated in larger controlled studies.

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