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abstract
Highlights
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- Laparoscopic fertility-sparing treatment of early ovarian cancer shows encouraging survival outcomes.
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- After conservative treatment, 64.8% woman reported pregnancy intent and 60% of these conceived spontaneously.
Objective
There
is as yet limited evidence about fertility-sparing surgery for early
ovarian cancer (EOC) carried out laparoscopically. We sought to
investigate the safety, adequacy and fertility outcome of ovarian cancer
patients who underwent fertility-saving laparoscopic surgical staging
using a multi-institutional sample.
Methods
Prospectively
collected data in five gynecologic oncology service databases were
searched for epithelial EOC patients undergoing laparoscopic
fertility-preserving surgery. Surgical, pathologic, oncologic and
reproductive outcome data were analysed.
Results
The
study cohort consisted of 65 women. Median age of the patients was 33
(range: 21–42) years. In this cohort 36 (55.4%) and 29 (44.6%) patients
were at low risk (FIGO stage IA G1–2) and high-risk (FIGO stage IA G3 or
more), respectively. The disease was reclassified to a higher stage in 4
(6.1%) women. After a median follow up period of 38 months (range:
2–144), the overall survival was 95.4% and recurrence-free survival
84.6%. Overall, there were 23 pregnancies in 22 women. After ovarian
cancer treatment, 64.8% women reported pregnancy intent and 60% of these
conceived spontaneously.
Conclusions
Laparoscopic
staging may represent a viable option for premenopausal women seeking
fertility preservation in the setting of early ovarian cancer. More
research is needed to determine whether laparoscopy may offer
reproductive benefits to this particular population.
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