Prediction of taxane and platinum sensitivity in ovarian cancer based on gene expression profiles Ovarian Cancer and Us OVARIAN CANCER and US Ovarian Cancer and Us

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Saturday, April 09, 2016

Prediction of taxane and platinum sensitivity in ovarian cancer based on gene expression profiles



abstract (technical)
 

Highlights

Gene expression-driven scores predict platinum/taxane response
Association of proposed scores with HGSOC gene expression subtypes
Complimentary roles of platinum and taxane for personalized therapy

Objective

Prognoses of ovarian cancer (OC) have improved with the paclitaxel-carboplatin regimen. However, it remains unclear which cases exhibit a genuine benefit from taxane or from platinum. We aimed to predict taxane and platinum sensitivity in OC via gene expression.

Conclusions

Our proposal and finding of a scoring system that could predict platinum or taxane response could be useful to develop individualized treatments to ovarian cancer.

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