Correspondence: Where Are We Headed With Research in Frail Elderly Patients With Cancer? Ovarian Cancer and Us OVARIAN CANCER and US Ovarian Cancer and Us

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Monday, August 22, 2016

Correspondence: Where Are We Headed With Research in Frail Elderly Patients With Cancer?



Where Are We Headed With Research in Frail Elderly Patients With Cancer?

 We should ask ourselves two key questions: Are we properly identifying the frail elderly patient with cancer who comes to our consulting rooms? And do we have sufficient scientific evidence to decide whether to treat this patient with chemotherapy? If we want to treat this population group to the best of our ability, we should be able to answer these questions.
 To the Editor:
The article by Corre et al1 described the ESOGIA (Elderly Selection on Geriatric Index Assessment) trial that was carried out in French and Spanish hospitals and that included elderly patients age 70 years or older with advanced non–small-cell lung cancer. The article provides hitherto unpublished information about the ability of a comprehensive geriatric assessment (CGA) to classify elderly patients with cancer and about its usefulness in decision making in this age group. CGA has already demonstrated its superiority in evaluating the elderly by providing more information than simply the patient’s performance status2 and by giving a more reliable prediction of the risk of toxicity with chemotherapy.3,4 In addition, different components of the CGA have independently demonstrated its ability to predict the toxicity of chemotherapy.3-5 Recently, the oncological-multidimensional prognostic index (Onco-MPI), which is based on the CGA, has proved to be a good predictive tool for 1-year mortality in older patients with cancer.6 Despite many relevant advances, it seems that not all of the efforts to reach a specific and definitive conclusion with regard to selecting treatment for elderly patients with cancer are heading in the same direction.....


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