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1. CORRESPONDENCE Population Frequency of Germline BRCA1/2 Mutations JCO published online on August 22, 2016; DOI:10.1200/JCO.2016.67.0554.

   ...highly penetrant for hereditary breast and ovarian cancer syndrome, with lifetime risks-dependent...to 70% for breast and 15% to 55% for ovarian cancer. 2 BRCA1/2 mutations also lead...high-risk familial hereditary breast and ovarian cancer may not be applicable in the discussion...

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2. CORRESPONDENCE Reply to S.M. Sorscher and M.J. Hall et al JCO published online on August 22, 2016; DOI:10.1200/JCO.2016.69.1022.

   ...without a known family history of breast or ovarian cancer. 8 Whereas Axilbund questions...mutations has been demonstrated in epithelial ovarian cancers 13 ; however, it is still not...mutations significantly increase the risk of ovarian cancer, and if so, by how much. Only...

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3. CORRESPONDENCE Multigene Panels to Evaluate Hereditary Cancer Risk: Reckless or Relevant? JCO published online on August 22, 2016; DOI:10.1200/JCO.2016.68.6725.

   ...management, both women were counseled about increased BC and ovarian cancer risks conferred by BRCA1/2 and were offered follow-up...actionability of multigene panel testing for hereditary breast and ovarian cancer risk assessment. JAMA Oncol 1:943-951, 2015...

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4. CORRESPONDENCE Reply to M.J. Hall et al and K.N. Maxwell et al JCO published online on August 22, 2016; DOI:10.1200/JCO.2016.69.1964.

   ...were developed primarily on the basis of penetrance in families that were phenotypically consistent with hereditary breast and ovarian cancer or Lynch syndrome, respectively. It remains to be seen what the penetrance ranges will be in patients and/or families...

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   ORIGINAL REPORTS - Epidemiology Ovarian Cancer Risk Factors by Histologic Subtype: An Analysis From the Ovarian Cancer Cohort Consortium JCO Aug 20, 2016:2888-2898; DOI:10.1200/JCO.2016.66.8178.

   ...REPORTS Epidemiology EPID1 EPID3 GYNC15 Ovarian Cancer Risk Factors by Histologic Subtype: An Analysis From the Ovarian Cancer Cohort Consortium Nicolas Wentzensen...understanding of the etiologic heterogeneity of ovarian cancer is important for improving prevention...

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   ORIGINAL REPORTS - Gynecologic Cancer Randomized Phase III Trial of Irinotecan Plus Cisplatin Compared With Paclitaxel Plus Carboplatin As First-Line Chemotherapy for Ovarian Clear Cell Carcinoma: JGOG3017/GCIG Trial JCO Aug 20, 2016:2881-2887; DOI:10.1200/JCO.2016.66.9010.

   ...Carboplatin As First-Line Chemotherapy for Ovarian Clear Cell Carcinoma: JGOG3017/GCIG...demonstrates poor outcomes in epithelial ovarian cancer. The Japanese Gynecologic Oncology...improving the prognosis of CCC. INTRODUCTION Ovarian cancer is the seventh most common cancer...

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   ORIGINAL REPORTS - Cancer Prevention and Control Randomized Noninferiority Trial of Telephone Delivery of BRCA1/2 Genetic Counseling Compared With In-Person Counseling: 1-Year Follow-Up JCO Aug 20, 2016:2914-2924; DOI:10.1200/JCO.2015.65.9557.

   ...at risk of hereditary breast and/or ovarian cancer living in geographically diverse...increased risk of hereditary breast and/or ovarian cancer were randomly assigned to in-person...between BRCA1/2 mutations and breast and ovarian cancer 1-10 has led to an increased...

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   ORIGINAL REPORTS - Rapid Communication Use and Costs of Disease Monitoring in Women With Metastatic Breast Cancer JCO Aug 20, 2016:2820-2826; DOI:10.1200/JCO.2016.66.6313.

   ...progression. 41,42 A study of 154 women with ovarian cancer found that on average, most women...and distress in women with epithelial ovarian cancer. Gynecol Oncol 100:495-500...Early versus delayed treatment of relapsed ovarian cancer (MRC OV05/EORTC 55955): A...

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   ORIGINAL REPORTS - Immunotherapy Safety, Antitumor Activity, and Immune Activation of Pegylated Recombinant Human Interleukin-10 (AM0010) in Patients With Advanced Solid Tumors JCO published online on August 15, 2016; DOI:10.1200/JCO.2016.68.1106.

   ...RCC, pancreatic ductal adenocarcinoma, ovarian cancer, prostate cancer, non-small-cell...cancer 4 12.1 Melanoma 4 12.1 NSCLC 1 3 Ovarian cancer 1 3 Prostate cancer 1 3 RCC (dose...Pancreatic cancer 2 (4) 1 SD (4) Ovarian cancer 1 (1) 1 SD (2) All patients...

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    ORIGINAL REPORTS - Breast Cancer Age- and Tumor Subtype–Specific Breast Cancer Risk Estimates for CHEK2*1100delC Carriers JCO Aug 10, 2016:2750-2760; DOI:10.1200/JCO.2016.66.5844.

    ...German Consortium for Hereditary Breast Ovarian Cancer Germany Population-based familial...into Familial Breast Cancer/Australian Ovarian Cancer Study Australia and New Zealand...population-based case-control study of ovarian cancer (controls only) 1,539 13 0...

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