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open access
Background
Ovarian cancer patients
have a high risk of developing venous thrombosis. The membrane lipid
bilayer of platelets and platelet-derived microparticles (PMP) provides a
platform for assembly of coagulation proteins and generation of blood
clots.
Conclusion
Our results support a
procoagulant lipid profile of platelets in ovarian cancer patients that
can play a role in the increased risk of venous thrombosis in these
patients.....
General significance
As
far as we are aware, our study is the first study on platelet
lipidomics in ovarian cancer. The importance of our findings for the
future studies are: 1) a similar change in lipid profile of platelets
and PMP may be responsible for hypercoagulability in other cancers, and
2) plasma level of high-risk lipids for venous thrombosis may be useful
biomarkers.
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