|
|
|
|
|
|
|
|
abstract
Introduction
To
evaluate the published literature on epidemiologic risk factors for
epithelial ovarian cancer (EOC) among women with a diagnosis of
endometriosis.
Material and methods
A
systematic literature search was conducted in PubMed and Scopus.
Studies comparing epidemiologic risk factors of EOC among women with
endometriosis were included. A quality assessment was conducted using
the Newcastle-Ottawa Scale.
Results
Eight
of 794 articles met the inclusion criteria; all were case-control
studies. A lower risk of EOC was observed in women with documented
complete surgical excision of endometriotic tissue and suggested among
women with unilateral oophorectomy. The use of oral contraceptives (≥10
years) may be associated with a lower risk of EOC among women with
endometriosis, whereas older age at endometriosis diagnosis (≥45 years,
pre- or postmenopausal), nulliparity, hyperestrogenism (endogenous or
exogenous), pre-menopausal status at endometriosis diagnosis solid
compartments as well as larger size of endometrioma (≥9 cm in diameter
at endometriosis diagnosis) were all associated with an increased risk
of ovarian cancer.
Conclusion
A
subgroup of women with endometriosis characterized by endometriosis
observed through surgery or imaging after the age of 45 years,
nulliparity, post-menopausal status at endometriosis diagnosis, larger
size of endometrioma (>9cm) at endometriosis diagnosis,
hyperestrogenism (endogenous or exogenous) and/or cysts with solid
compartments may have an elevated risk of EOC. However, due to the
limited number and size of studies in this area we cannot draw
definitive conclusions. Further research into a risk factor profile
among women with endometriosis is needed before clear recommendations
can be made.
0 comments :
Post a Comment
Your comments?
Note: Only a member of this blog may post a comment.