abstract
BACKGROUND/AIM:
Second primary tumors (SPTs) often occur, either synchronous or metachronous.
Struma ovarii is a rare ovarian
tumor represented by thyroid tissue in the ovary. Among other factors,
production of thyroid hormones by the tumor or a shared genetic
predisposition can further influence the development of SPTs.
The
occurrence of SPT, either synchronous or metachronous, following a long
follow-up, has never been considered extensively.
PATIENTS AND METHODS:
We
analyzed the Surveillance, Epidemiology, and End Results (SEER)
database from 1973 to 2011 to follow-up all the cases of malignant
struma ovarii in an effort of calculate the occurrence of SPTs in this
cohort of patients.
RESULTS:
We
identified
21 patients with malignant struma ovarii in the period
between January 1973 and December 2011. In a follow-up period of 219.57
person-years, 3 patients had SPT. One patient had synchronous thyroid
sclerosing carcinoma, 1 patient had metachronous papillary
adenocarcinoma with a latent time of 7 years and 1 patient had
synchronous salivary ductal carcinoma.
CONCLUSION:
Up
to date, only thyroid synchronous tumors have been reported in the
literature. A synchronous and a metachronous thyroid tumor, plus a
synchronous salivary gland tumor, were found. A significant association
between malignant struma ovarii and thyroid/salivary gland
cancer is herein demonstrated.
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