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abstract:
Does time interval between surgery and intraperitoneal chemotherapy administration in advanced ovarian cancer carry a prognostic impact? An NRG Oncology/Gynecologic Oncology Group study ancillary study
Hence, the relationship between IP chemotherapy initiation and time from surgery needs to be studied further.
Highlights
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- Time from surgery to IP chemotherapy initiation (TSIC) did not impact survival.
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- Gross residual disease was significantly associated with shorter TSIC.
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- Gross residual disease significantly associated with higher risk of progression.
Objectives
To
determine the relationship of the time from surgery to intraperitoneal
(IP) chemotherapy (TSIC) initiation with survival of patients with stage
III epithelial ovarian cancer (EOC) patients using ancillary data from
cooperative group clinical trials.
Methods
Data
from 420 patients with stage III EOC treated with IP chemotherapy under
GOG-0114 and 172 were reviewed.
The Cox proportional hazards model was
used to evaluate independent prognostic factors and estimate their
covariate-adjusted effects on PFS and OS.Results
The
median TSIC was 62.5 days (interquartile range 28–83). The median TSIC
was longer for patients in GOG-0114 vs those in GOG-172 (83 vs 26 days,
p < 0.001). TSIC was significantly associated (p = 0.049) with PFS:
each 10% increase in TSIC (days) decreases the risk of progression by
3%. TSIC was not significantly associated with OS in this model. In a
linear regression model, gross residual disease was significantly
associated with shorter TSIC (R2 − 0.141, 95%CI − 0.217,
− 0.064, p < 0.001). When only data from GOG-172 were considered, no
statistical significant association was found between TSIC and PFS or
OS.
Conclusions
In this
ancillary data study, TSIC was not associated with improved OS in
patients with stage III epithelial ovarian cancer. TSIC was
significantly associated with PFS for the entire cohort, suggesting
increase in PFS with longer TSIC. However, this was not found when only
data from GOG 172 or GOG 114 were analyzed separately. Hence, the
relationship between IP chemotherapy initiation and time from surgery
needs to be studied further.
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