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abstract
Highlights
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- Early stage (I-IIA) epithelial ovarian cancer can only be properly defined by a thorough and comprehensive surgical staging.
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- The completeness of surgical staging is an independent prognostic factor for survival and disease free survival in early stage ovarian carcinoma.
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- The effectiveness of adjuvant chemotherapy in properly staged early stage ovarian carcinoma is questionable.
The
treatment of early stage (stage I-IIA) ovarian carcinoma is
predominantly surgical and the surgical staging is the most relevant
step in the treatment of this disease. The significance of surgical
staging is twofold. First, proper staging distinguishes between ‘real’
early stage ovarian carcinoma and ‘perhaps’ early stage disease. The
latter carries an appreciable likelihood of unappreciated residual
disease in between 16 and 42% of cases. Second, there is solid proof
that proper surgical staging is an independent prognostic factor for
improved disease-free and overall survival in early stage ovarian
carcinoma. The relevance of various staging steps are discussed and
surgical guidelines are given in this chapter.
The
indication for adjuvant chemotherapy after surgery is closely related
to the adequacy of surgical staging. Adjuvant chemotherapy only works in
patients in whom surgical staging was inadequate and who, thus, remain
with a certain risk of unnoticed residual intraperitoneal or
retroperitoneal tumour spread. On the other hand, there is no indication
that adjuvant chemotherapy is of any value after an adequate,
comprehensive staging procedure. Controversies and misunderstandings on
this important issue are discussed.
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