Impact of the new FIGO 2013 classification on survival analysis of stage I epithelial ovarian cancer Ovarian Cancer and Us OVARIAN CANCER and US Ovarian Cancer and Us

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Saturday, October 22, 2016

Impact of the new FIGO 2013 classification on survival analysis of stage I epithelial ovarian cancer



Abstract

Introduction: The FIGO classification for ovarian cancer, has recently been revised: FIGO IC subdivided in IC1 (intraoperative surgical spill), IC2 (capsule rupture before surgery, tumor on surface) and IC3 (positive peritoneal washing). Our aim is to compare the outcome of patients in the new FIGO I subgroups as this might influence adjuvant therapy desicion.

Materials and Methods: Patient databases of three gynecological oncology centers were retrospectively analyzed. Patients with FIGO I ovarian or tubal cancer were included and restaged according to the revised version and compared them to patient outcome data.

Results: 208 patients were analyzed (IA 59.1%; IB 7.2%; IC1 8.7%; IC2 7.7%; IC3 17.3%). In FIGO IA we found 11.5% recurrences and 4.3% deaths, comparing to 23% and 3.8% respectively in FIGO IC and time to recurrence was 190 vs. 158 months (p = 0.061). Within all new subgroups of FIGO IC, there was no difference in time to recurrence; 91.2 (IC1), 83.7 (IC2), and 78.2 (IC3) months (p = 0.68). There was also no difference in survial when FIGO IA was compared to FIGO IC in comparison to the new classifications (IA to IC or IA to IC1, 2 or 3, respectively; p = 0.93, p = 0.66, p = 0.71, p = 0.64) or within the different subgroups (p = 0.47). No difference in regards to the tumorboard when comparing FIGO IC1 and IC3.

Conclusion: The new FIGO staging of IC ovarian cancers didn't predict prognosis nor change tumorboard decisions. Larger numbers and individual histotype depending analyses may be warranted.

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