The role of the androgen receptor in ovarian cancer carcinogenesis and its clinical implications | Zhu | Oncotarget Ovarian Cancer and Us OVARIAN CANCER and US Ovarian Cancer and Us

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Saturday, October 22, 2016

The role of the androgen receptor in ovarian cancer carcinogenesis and its clinical implications | Zhu | Oncotarget



open access

AR expression in human ovarian cancer

A large body of evidence has consistently vindicated over-expression of AR in ovarian cancers. In an early report, Hamilton et al. [18] demonstrated AR expression in ovarian cancers using ligand binding assays. Further studies showed AR expression was detected in about 90% of epithelial ovarian cancers by biochemical receptor assay [19] and 43.5-86% by immunohistochemistry. [20-23] Curiously in recent studies, AR expression has commonly been detected just as frequently as the estrogen receptor and more frequently than the progesterone receptor in ovarian cancer samples [21, 24]....

 Table 2: Prognostic significance of AR and AR alleles in ovarian cancer

  Increased AR expression likely predicts a favorable prognosis in     epithelial ovarian cancer.

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