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abstract
Highlights
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- Black tea consumption may increase epithelial ovarian cancer risk.
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- The excess risk is most relevant for the endometrioid histotype.
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- Study strength: adult lifetime tea, coffee, and caffeinated beverage consumption.
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- Study Strength: evaluation of types of tea—caffeinated/black tea and green tea.
Background
The
risk for epithelial ovarian cancer associated with the consumption of
caffeinated beverages (tea, coffee, and soft drinks) and green tea is
inconclusive. However, few studies have investigated the type of
caffeinated beverage or the type of tea.
Objective
We
assessed consumption of tea (black/caffeinated tea and green tea
separately), coffee, and caffeinated soft drinks, as well as level of
consumption, and the risk for epithelial ovarian cancer and its
histotypes.
Study design
This
study was conducted within a population-based case-control study in
Alberta and British Columbia, Canada from 2001 to 2012. After
restricting to cases of epithelial invasive cancers and controls aged
40–79 years who completed an interview that included coffee, soft drink,
and tea consumption (ascertained starting in 2005 in British Columbia
and 2008 in Alberta), there were a total of 524 cases and 1587 controls.
Those that did not meet the threshold for beverage consumption (at
least once per month for 6 months or more) were classified as
non-drinkers. Adult lifetime cumulative consumption
(cup-years = cups/day * years) was calculated. Unconditional logistic
regression was used to estimate adjusted odds ratios (aOR) and 95%
confidence intervals (CI) to describe the association between the
relevant drink consumption and risk.
Results
No
excess risk was seen for coffee or caffeinated soft drinks. Similarly,
any tea consumption was not associated with risk, but when stratified by
the type of tea, there was an increase in risk in black tea only
drinkers (aOR = 1.56; 95% CI:1.07–2.28 for >40 cup-years), but no
excess risk for the exclusive green tea drinkers. Similar findings were
observed for post-menopausal women. The association for black tea only
consumption was mainly seen in the endometrioid histotype (aOR = 3.19;
95% CI: 1.32–7.69).
Conclusion
Black
tea consumption may be associated with an increased risk epithelial
ovarian carcinoma. The excess risk is seen only in the endometrioid
histotype but not in serous or clear cell. Further studies are required
to confirm these findings and identify the constituents in black tea
that may increase the risk.
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