Commentary on microRNA Fingerprint in Human Epithelial Ovarian Cancer | Cancer Research Ovarian Cancer and Us OVARIAN CANCER and US Ovarian Cancer and Us

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Saturday, November 05, 2016

Commentary on microRNA Fingerprint in Human Epithelial Ovarian Cancer | Cancer Research



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See related article by Iorio et al., Cancer Res 2007;67:8699–707.
 
The highlighted article (1) described for the first time the miRNA aberrant expression in human epithelial ovarian cancer. Along with the miRNA profiling we performed in human breast cancer a couple of years earlier, it represents a pioneer study in the field of miRNAs and one of the first reports describing the involvement of these small noncoding RNA molecules in solid tumors.
miRNAs underwent a long period of silence after their initial discovery back in 1993.......In our study on human epithelial ovarian cancer, miRNA signatures were also able to discriminate among different tumor subgroups, providing an extremely important message, afterward applied to different human neoplasms. These small noncoding RNA molecules are not only altered in neoplastic cells in comparison with the corresponding normal tissue, but they also have potential as diagnostic biomarkers.....
  A deeper understanding of miRNA function and their interaction with therapeutics is also still required. Nevertheless, the results obtained in this field of research are certainly exciting and encouraging, and miRNAs may have a great potential in revolutionizing cancer diagnostics and personalized medicine in the coming years.

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