Preclinical development of a preventive vaccine against ovarian cancer | Cancer Immunology Research Ovarian Cancer and Us OVARIAN CANCER and US Ovarian Cancer and Us

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Saturday, November 05, 2016

Preclinical development of a preventive vaccine against ovarian cancer | Cancer Immunology Research



Abstract

 ...These results support the hypothesis that a vaccine regimen combining mesothelin with CDN and Addavax can protect against aggressive forms of ovarian cancer. A similar vaccination study is in progress implementing a new model of inducible ovarian cancer in mice carrying floxed alleles of Dicer and PTEN. Prevention of ovarian cancer may be possible by vaccination against mesothelin tumor antigen in combination with adjuvants that stimulate type I IFN response.

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