Showing posts with label Claudin 5. Show all posts
Showing posts with label Claudin 5. Show all posts
Wednesday, May 09, 2012
VEGF induces ascites in ovarian cancer patients via increasing peritoneal permeability by downregulation of Claudin 5
VEGF induces ascites in ovarian cancer patients via increasing peritoneal permeability by downregulation of Claudin 5
Objective
To evaluate the role of VEGF-dependent Claudin 5 production for the development of ascites via influencing endothelial permeability in peritoneal tissue of ovarian cancer patients.
Conclusion
VEGF induces ascites in ovarian cancer patients. This instance happens due to increased peritoneal permeability, caused by downregulation of the tight junction protein Claudin 5 in the peritoneal endothelium.
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