Genetics of Breast and Ovarian Cancer (PDQ®) - NCI - rare syndrome (LFS, Cowden, PJS)

Other Rare Breast and Ovarian Cancer-Associated Syndromes
Li-Fraumeni syndrome
Cowden syndrome
Peutz-Jeghers syndrome

Cancer: Cowden Syndrome: Cancer Center: UI Health Topics (thyroid, breast, ovarian....)

"The breast and thyroid are the two most common sites for cancer development. "

"Cancers of the colon, skin, kidney, small bowel, stomach, ovary, and lung have been reported in individuals diagnosed with Cowden syndrome, but a true association between CS and the risk for cancer has not been proven. Because these risks are not clearly known, surveillance is an important part of your health care program."

Genetic/Familial High-Risk Assessment: Breast and Ovarian — J Natl Compr Canc Network NCCN

Note: full free access; includes risks of Li-Fraumeni, Cowden and Lynch Syndromes

Mutations in gene protecting body leads to development of cancer

Note: the PTEN mutation has and is being widely studied in ovarian cancer

"The study examined mutations in a gene called PTEN. People who inherit a mutated copy of this gene have Cowden syndrome, a condition that carries a high risk of cancer in a number of organs, including the breast, thyroid and ovary. In addition, PTEN is frequently mutated in normal body cells leading to prostate, lung and pancreatic cancers."

Abstract - Cancer predisposition: I say genetics, you say genomics, but are we there yet? -- Cancer Prevention Research

"A few examples include Lynch syndrome, hereditary breast-ovarian cancer syndrome and Cowden syndrome."